泛素与 ESCRTs 的作用方式。
How ubiquitin functions with ESCRTs.
机构信息
Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA 52246, USA.
出版信息
Traffic. 2011 Oct;12(10):1306-17. doi: 10.1111/j.1600-0854.2011.01242.x. Epub 2011 Jul 27.
Abstract
The endosomal-sorting complex required for transport (ESCRT) apparatus has multiple ubiquitin (Ub)-binding domains and participates in a wide variety of cellular processes. Many of these ESCRT-dependent processes are keenly regulated by Ub, which serves as a lysosomal-sorting signal for membrane proteins targeted into multivesicular bodies (MVBs) and which may serve as a mediator of viral budding from the cell surface. Hints that both ESCRTs and Ub work together in the processes such as cytokinesis, transcription and autophagy are beginning to emerge. Here, we explore the relationship between ESCRTs and Ub in MVB sorting and viral budding.
摘要
内体分选复合物需要运输（ESCRT）设备具有多个泛素（Ub）结合域，并参与多种细胞过程。这些 ESCRT 依赖的过程中的许多都受到 Ub 的严格调控，Ub 是靶向到多泡体（MVB）的膜蛋白的溶酶体分拣信号，并且可能作为细胞表面病毒出芽的介质。有迹象表明 ESCRTs 和 Ub 在细胞分裂、转录和自噬等过程中协同工作。在这里，我们探讨了 ESCRTs 和 Ub 在 MVB 分拣和病毒出芽中的关系。
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