前列腺素 E2 在造血中的多效作用；前列腺素 E2 和其他类二十烷酸调节造血干细胞和祖细胞功能。
Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function.
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):3-9. doi: 10.1016/j.prostaglandins.2011.06.004. Epub 2011 Jun 21.
Abstract
Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E(2) in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, survival and self-renewal. We also describe a role for cannabinoids in hematopoiesis. Lastly, we discuss the yin and yang of various eicosanoids in modulating hematopoietic stem and progenitor cell functions and summarize potential strategies to take advantage of these effects for therapeutic benefit for hematopoietic stem cell transplantation.
摘要
类二十烷酸在造血生理调节中发挥作用，对造血干细胞和各种谱系限制祖细胞具有多效性影响。在此，我们综述了类二十烷酸对造血的影响，重点介绍了前列腺素 E2 通过增强干细胞归巢、存活和自我更新来增强造血干细胞植入的新发现。我们还描述了大麻素在造血中的作用。最后，我们讨论了各种类二十烷酸在调节造血干细胞和祖细胞功能中的阴阳两面，并总结了利用这些作用治疗造血干细胞移植的潜在策略。
相似文献
1
Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function.前列腺素 E2 在造血中的多效作用；前列腺素 E2 和其他类二十烷酸调节造血干细胞和祖细胞功能。
Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):3-9. doi: 10.1016/j.prostaglandins.2011.06.004. Epub 2011 Jun 21.
2
Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking.二十烷酸类物质对造血作用和造血干细胞及祖细胞归巢的调控。
Leukemia. 2010 Dec;24(12):1993-2002. doi: 10.1038/leu.2010.216. Epub 2010 Sep 30.
3
Pathways implicated in stem cell migration: the SDF-1/CXCR4 axis.与干细胞迁移相关的信号通路：SDF-1/CXCR4轴。
Methods Mol Biol. 2011;750:277-89. doi: 10.1007/978-1-61779-145-1_19.
4
Pharmacologic increase in HIF1α enhances hematopoietic stem and progenitor homing and engraftment.药物增加 HIF1α 可增强造血干细胞和祖细胞归巢和植入。
Blood. 2014 Jan 9;123(2):203-7. doi: 10.1182/blood-2013-07-516336. Epub 2013 Oct 28.
5
Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation.前列腺素E2可增强造血干细胞归巢、存活及增殖能力。
Blood. 2009 May 28;113(22):5444-55. doi: 10.1182/blood-2009-01-201335. Epub 2009 Mar 26.
6
Stromal-derived factor-1/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow.基质细胞衍生因子-1/CXCR4 信号：在造血干细胞归巢和植入骨髓中不可或缺的作用。
Stem Cells Dev. 2011 Jun;20(6):933-46. doi: 10.1089/scd.2010.0263. Epub 2011 Feb 2.
7
Chemokines in hematopoiesis.造血过程中的趋化因子。
Curr Opin Hematol. 2008 Jan;15(1):49-58. doi: 10.1097/MOH.0b013e3282f29012.
8
Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment.通过组蛋白去乙酰化酶 5 中和负性表观遗传调控可增强人造血干细胞归巢和植入。
Nat Commun. 2018 Jul 16;9(1):2741. doi: 10.1038/s41467-018-05178-5.
9
SMAD signaling regulates CXCL12 expression in the bone marrow niche, affecting homing and mobilization of hematopoietic progenitors.SMAD信号通路调节骨髓微环境中CXCL12的表达，影响造血祖细胞的归巢和动员。
Stem Cells. 2014 Nov;32(11):3012-22. doi: 10.1002/stem.1794.
10
Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis--Lessons From Pharmacological and Genetic Models.简明综述：CXCR4/CXCL12 信号在未成熟造血中的作用——来自药理学和遗传学模型的启示。
Stem Cells. 2015 Aug;33(8):2391-9. doi: 10.1002/stem.2054. Epub 2015 May 25.
引用本文的文献
1
Disruption of the PGE synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice.前列腺素E合成/反应途径的破坏可抑制程序性细胞死亡蛋白1（Pd-1）缺陷型高脂血症小鼠的动脉粥样硬化形成。
bioRxiv. 2024 Sep 15:2024.07.02.601762. doi: 10.1101/2024.07.02.601762.
2
Pharmacokinetics and Biodistribution of 16,16 dimethyl Prostaglandin E2 in Non-Irradiated and Irradiated Mice and Non-Irradiated Non-Human Primates.16,16-二甲基前列腺素E2在未受照射和受照射小鼠以及未受照射的非人类灵长类动物中的药代动力学和生物分布
Radiat Res. 2024 Jan 1;201(1):7-18. doi: 10.1667/RADE-23-00040.1.
3
The Role of COX-2 and PGE2 in the Regulation of Immunomodulation and Other Functions of Mesenchymal Stromal Cells.COX-2和PGE2在间充质基质细胞免疫调节及其他功能调控中的作用
Biomedicines. 2023 Feb 3;11(2):445. doi: 10.3390/biomedicines11020445.
4
Optimizing and Profiling Prostaglandin E2 as a Medical Countermeasure for the Hematopoietic Acute Radiation Syndrome.优化和分析前列腺素 E2 作为造血急性辐射综合征的医疗对策。
Radiat Res. 2021 Feb 1;195(2):115-127. doi: 10.1667/RADE-20-00181.1.
5
A Single Radioprotective Dose of Prostaglandin E Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells.单次放射防护剂量的前列腺素 E 阻断辐射诱导的造血干细胞凋亡信号和早期周期。
Stem Cell Reports. 2020 Aug 11;15(2):358-373. doi: 10.1016/j.stemcr.2020.07.004. Epub 2020 Jul 30.
6
Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation.巨噬细胞中的促红细胞生成素受体信号转导改变了脾脏龛位，促进了红细胞分化。
Blood. 2020 Jul 9;136(2):235-246. doi: 10.1182/blood.2019003480.
7
Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome.前列腺素简述、其合成抑制剂、造血作用和急性辐射综合征。
Molecules. 2019 Nov 6;24(22):4019. doi: 10.3390/molecules24224019.
8
An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.一个由 ARC 调控的 IL1β/Cox-2/PGE2/β-Catenin/ARC 回路控制白血病微环境相互作用，并赋予 AML 耐药性。
Cancer Res. 2019 Mar 15;79(6):1165-1177. doi: 10.1158/0008-5472.CAN-18-0921. Epub 2019 Jan 23.
9
Prostaglandin E2 promotes human CD34+ cells homing through EP2 and EP4 in vitro.前列腺素E2在体外通过EP2和EP4促进人CD34+细胞归巢。
Mol Med Rep. 2017 Jul;16(1):639-646. doi: 10.3892/mmr.2017.6649. Epub 2017 May 30.
10
Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation.在小分子筛选中鉴定出的粉防己碱可激活间充质干细胞以增强免疫调节作用。
Sci Rep. 2016 Jul 26;6:30263. doi: 10.1038/srep30263.
本文引用的文献
1
The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood.细胞色素 P450 4A/F-20-羟二十碳四烯酸系统：人脐血内皮祖细胞的调节因子。
J Pharmacol Exp Ther. 2011 Aug;338(2):421-9. doi: 10.1124/jpet.111.179036. Epub 2011 Apr 28.
2
Pulse exposure of haematopoietic grafts to prostaglandin E2 in vitro facilitates engraftment and recovery.体外给予造血移植物前列腺素 E2 脉冲暴露可促进植入和恢复。
Cell Prolif. 2011 Apr;44 Suppl 1(Suppl 1):22-9. doi: 10.1111/j.1365-2184.2010.00726.x.
3
Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.前列腺素 E2 增强了人脐血干细胞异种移植，并在临床前非人类灵长类动物移植模型中显示出长期安全性。
Cell Stem Cell. 2011 Apr 8;8(4):445-58. doi: 10.1016/j.stem.2011.02.003.
4
Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.大麻素受体 2 及其激动剂可调节造血以及造血干细胞和祖细胞的动员。
Blood. 2011 Jan 20;117(3):827-38. doi: 10.1182/blood-2010-01-265082. Epub 2010 Nov 9.
5
A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors.高ω-3脂肪酸饮食对早期和晚期髓系祖细胞有不同影响。
Lipids. 2011 Jan;46(1):47-57. doi: 10.1007/s11745-010-3491-3. Epub 2010 Oct 31.
6
Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking.二十烷酸类物质对造血作用和造血干细胞及祖细胞归巢的调控。
Leukemia. 2010 Dec;24(12):1993-2002. doi: 10.1038/leu.2010.216. Epub 2010 Sep 30.
7
Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment.内源性大麻素在骨髓基质龛中表达，并在造血干细胞和祖细胞与骨髓微环境的相互作用中发挥作用。
J Biol Chem. 2010 Nov 12;285(46):35471-8. doi: 10.1074/jbc.M110.144758. Epub 2010 Sep 7.
8
Hematopoietic stem cell lodgment in the adult bone marrow stem cell niche.造血干细胞在成人骨髓干细胞龛中的定位。
Int J Lab Hematol. 2010 Dec;32(6 Pt 2):551-8. doi: 10.1111/j.1751-553X.2010.01250.x.
9
Newly emerging roles for prostaglandin E2 regulation of hematopoiesis and hematopoietic stem cell engraftment.前列腺素 E2 对造血和造血干细胞植入的新作用。
Curr Opin Hematol. 2010 Jul;17(4):308-12. doi: 10.1097/MOH.0b013e32833a888c.
10
Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism.造血干细胞功能需要 12/15-脂氧合酶依赖的脂肪酸代谢。
Blood. 2010 Jun 17;115(24):5012-22. doi: 10.1182/blood-2009-09-243139. Epub 2010 Mar 31.
Zotero 插件