CTLA-4 外显子 1+49A>G 多态性与原发性胆汁性肝硬化风险的关联：一项荟萃分析。

Association between CTLA-4 exon-1 +49A>G polymorphism and primary biliary cirrhosis risk: a meta-analysis.

机构信息

Department of Hepato-Biliary Surgery, Anhui Provincial Hospital Affiliated with Anhui Medical University, Anhui, China.

出版信息

Arch Med Res. 2011 Apr;42(3):235-8. doi: 10.1016/j.arcmed.2011.04.004.

DOI:10.1016/j.arcmed.2011.04.004

PMID:21722820

Abstract

BACKGROUND AND AIMS

CTLA-4 exon-1 +49A>G polymorphisms have been reported to influence the risk for primary biliary cirrhosis in many studies; however, the results still remain controversial and ambiguous. The aim of this study was to determine more precise estimations for the relationship between CTLA-4 exon-1 +49A>G polymorphisms and the risk for primary biliary cirrhosis.

METHODS

Electronic searches for all publications were conducted on associations between this variant and breast cancer in several databases through November 2010. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association. Eight studies were identified including 2151 cases and 2214 controls.

RESULTS

Overall, there were no significant associations between CTLA +49G>A polymorphism and primary biliary cirrhosis risk (codominant model: GA vs. AA OR=1.190, 95% CI=0.818-1.732; GG vs. AA OR=1.153, 95% CI=0.858-1.550; dominant model: OR=1.181, 95% CI=0.873-1.599; and recessive model: OR=1.148; 95% CI=0.903-1.459). In the subgroup analysis by ethnicity, a significantly increased risk was found for Asians (GG vs. AA OR=1.873; 95% CI=1.202-2.921) and recessive model (OR=1.758; 95% CI = 1.271-2.433). In the stratified analysis by control sources, significant association were observed in population-based studies (GA vs. AA OR=1.432; 95% CI=1.078-1.902).

CONCLUSIONS

This meta-analysis suggests that the CTLA-4 +49G>A polymorphism may be a risk factor for primary biliary cirrhosis in Asians.

摘要

背景和目的

CTLA-4 外显子 1+49A>G 多态性已被报道在许多研究中影响原发性胆汁性肝硬化的风险;然而，结果仍然存在争议和不明确。本研究的目的是确定更精确的 CTLA-4 外显子 1+49A>G 多态性与原发性胆汁性肝硬化风险之间的关系。

方法

通过电子搜索，在 2010 年 11 月之前在几个数据库中搜索了关于该变体与乳腺癌关联的所有出版物。计算粗比值比(ORs)和 95%置信区间(CI)来估计关联的强度。共确定了 8 项研究，包括 2151 例病例和 2214 例对照。

结果

总体而言，CTLA+49G>A 多态性与原发性胆汁性肝硬化风险之间无显著关联(共显性模型：GA 与 AA OR=1.190，95%CI=0.818-1.732;GG 与 AA OR=1.153，95%CI=0.858-1.550;显性模型：OR=1.181，95%CI=0.873-1.599;隐性模型：OR=1.148;95%CI=0.903-1.459)。按种族亚组分析，发现亚洲人( GG 与 AA OR=1.873;95%CI=1.202-2.921)和隐性模型(OR=1.758;95%CI=1.271-2.433)的风险显著增加。按对照来源分层分析，发现基于人群的研究存在显著相关性(GA 与 AA OR=1.432;95%CI=1.078-1.902)。