Department of Anesthesiology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, Fujian, China.
Mol Biol Rep. 2013 Jan;40(1):535-43. doi: 10.1007/s11033-012-2090-1. Epub 2012 Oct 29.
Transforming growth factor-β (TGF-β) protein has been supposed to be a risk factor for liver cirrhosis; however, the associations between its genes (TGF-β -509C>T and +869T>C) and liver cirrhosis remained unclear. This study was to quantitatively analyze the correlations by using a meta-analysis. Pubmed, Embase, Wanfang databases were retrieved up to November 1st, 2011. Odds ratio (OR) and 95 % confidence interval (95 %CI) were used to demonstrate the strength of association, and P < 0.05 of Z test indicated statistical significance. Combined analyses were performed by using fixed or random-effect model, depending on between-study heterogeneity. Seven studies were for TGF-β -509C>T polymorphism, and eight studies were for +869T>C polymorphism. Combined results indicated that neither TGF-β -509C>T nor +869T>C polymorphisms were associated with risk of liver cirrhosis [OR (95 % CI): 0.79 (0.60-1.04) for CT vs. TT of -509C>T and 0.87 (0.68-1.12) for CT vs. CC of +869T>C], with no between-study heterogeneity. In addition, subgroups analyses still inferred that two polymorphisms were not associated with risk of liver cirrhosis for HBV-infected patients, Asians and for Population-based studies. This meta-analysis indicated that neither TGF-β -509C>T nor +869T>C polymorphisms were associated with risk of liver cirrhosis, regardless of HBV infection or not.
转化生长因子-β（TGF-β）蛋白被认为是肝硬化的一个危险因素；然而，其基因（TGF-β-509C>T 和 +869T>C）与肝硬化之间的关系仍不清楚。本研究旨在通过荟萃分析定量分析这些关联。检索了 PubMed、Embase 和万方数据库，截止日期为 2011 年 11 月 1 日。使用优势比（OR）和 95%置信区间（95%CI）来表示关联的强度，Z 检验 P<0.05 表示具有统计学意义。根据研究间异质性，采用固定或随机效应模型进行合并分析。有 7 项研究用于 TGF-β-509C>T 多态性，有 8 项研究用于 +869T>C 多态性。合并结果表明，TGF-β-509C>T 和 +869T>C 多态性均与肝硬化风险无关[OR（95%CI）：-509C>T 的 CT 与 TT 为 0.79（0.60-1.04），+869T>C 的 CT 与 CC 为 0.87（0.68-1.12）]，且无研究间异质性。此外，亚组分析仍推断，这两种多态性与乙型肝炎病毒（HBV）感染患者、亚洲人和基于人群的研究中肝硬化的风险无关。本荟萃分析表明，无论 HBV 是否感染，TGF-β-509C>T 和 +869T>C 多态性均与肝硬化风险无关。
