Department of Food and Nutrition, Sunchon National University, Suncheon 540-742, Republic of Korea.
Food Chem Toxicol. 2011 Sep;49(9):2370-6. doi: 10.1016/j.fct.2011.06.049. Epub 2011 Jun 23.
The potential health benefits of tea have long been studied. This study examined the role of powdered sea buckthorn leaf tea (SLT) in high-fat diet-induced obese mice. The mice were fed two different doses of SLT (1% and 5%, wt/wt) for six weeks. SLT suppressed body weight gain in a dose-dependent manner and significantly reduced visceral fat, plasma levels of leptin, triglyceride and total cholesterol and ALT activity compared with the high-fat-fed control mice. SLT also decreased hepatic triglyceride and cholesterol concentrations and lipid accumulation, whereas elevated fecal lipid excretion. High-fat feeding resulted in simultaneously decreasing hepatic FAS and G6PD activities and increasing PAP, β-oxidation and CPT activities. However, SLT supplementation during high-fat feeding led to a significant decrease in PAP, β-oxidation and CPT activities with a simultaneous increase in G6PD activity. The hepatic CYP2E1 activity and hepatic and erythrocyte lipid peroxides were significantly lowered with SLT supplements. Hepatic and erythrocyte SOD and CAT activities were also increased with SLT supplements in a dose-dependent manner, whereas GSH-Px activity was increased in erythrocytes only. These results indicate that SLT has potential anti-visceral obesity and antioxidant effects mediated by the regulation of lipid and antioxidant metabolism in high-fat diet-induced obese mice.
茶的潜在健康益处早已被研究。本研究探讨了沙棘叶茶粉（SLT）在高脂肪饮食诱导肥胖小鼠中的作用。将两种不同剂量的 SLT（1%和 5%，wt/wt）喂食小鼠 6 周。与高脂肪喂养的对照组小鼠相比，SLT 以剂量依赖的方式抑制体重增加，并显著降低内脏脂肪、瘦素、甘油三酯和总胆固醇水平以及 ALT 活性。SLT 还降低了肝甘油三酯和胆固醇浓度以及脂质积累，同时增加了粪便脂质排泄。高脂肪喂养导致同时降低肝 FAS 和 G6PD 活性，增加 PAP、β-氧化和 CPT 活性。然而，在高脂肪喂养期间补充 SLT 导致 PAP、β-氧化和 CPT 活性显著降低，同时 G6PD 活性增加。SLT 补充剂还降低了肝和红细胞中的脂质过氧化物。SLT 补充剂还以剂量依赖的方式增加了肝和红细胞中的 SOD 和 CAT 活性，而仅在红细胞中增加了 GSH-Px 活性。这些结果表明，SLT 具有通过调节高脂肪饮食诱导肥胖小鼠的脂质和抗氧化代谢来发挥潜在的抗内脏肥胖和抗氧化作用。
