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食用沙棘果富含多酚的提取物后，健康人体中特定干细胞类型的快速和选择性动员。

Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries () in healthy human subjects.

机构信息

Biomx Stemceuticals, Austin, TX 78765, USA,

NIS Labs, Klamath Falls, OR 97601, USA.

出版信息

Clin Interv Aging. 2019 Feb 4;14:253-263. doi: 10.2147/CIA.S186893. eCollection 2019.

DOI:10.2147/CIA.S186893
PMID:30787601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6368418/
Abstract

PURPOSE

The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the blood circulation of healthy human subjects.

STUDY DESIGN AND METHODS

A randomized, double-blind, placebo-controlled, cross-over trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+ and CD45dim CD34+ CD309- stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ mesenchymal stem cells.

RESULTS

Consumption of SBB-PE was associated with a rapid and highly selective mobilization of CD45dim CD34+ CD309- progenitor stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ lymphocytoid mesenchymal stem cells. In contrast, only minor effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells.

CONCLUSION

Consumption of SBB-PE resulted in selective mobilization of stem cell types involved in regenerative and reparative functions. These data may contribute to the understanding of the traditional uses of SBB for preventive health, regenerative health, and postponing the aging process.

摘要

目的

本研究旨在评估沙棘果原花青素提取物（SBB-PE）对健康人体循环中各种类型成体干细胞数量的影响。

研究设计与方法

在 12 名健康受试者中进行了一项随机、双盲、安慰剂对照、交叉试验。受试者在服用安慰剂或 500mg SBB-PE 之前和之后 1 小时和 2 小时分别抽取血样。全血用于免疫表型和流式细胞术，以定量 CD45dim CD34+ CD309+和 CD45dim CD34+ CD309-干细胞、CD45-CD31+ CD309+内皮干细胞和 CD45-CD90+间充质干细胞的数量。

结果

SBB-PE 的摄入与 CD45dim CD34+ CD309-祖细胞干细胞、CD45-CD31+ CD309+内皮干细胞和 CD45-CD90+淋巴样间充质干细胞的快速且高度选择性动员相关。相比之下，仅观察到 CD45dim CD34+ CD309+多潜能干细胞的微小作用。

结论

SBB-PE 的摄入导致参与再生和修复功能的干细胞类型的选择性动员。这些数据可能有助于理解 SBB 用于预防性健康、再生健康和延缓衰老过程的传统用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/7346529d313b/cia-14-253Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/82e6cf696d75/cia-14-253Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/987ea174b615/cia-14-253Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/de28036910de/cia-14-253Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/7346529d313b/cia-14-253Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/82e6cf696d75/cia-14-253Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/987ea174b615/cia-14-253Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/de28036910de/cia-14-253Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af0/6368418/7346529d313b/cia-14-253Fig4.jpg

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