Graham N M, Burrell C J, Douglas R M, Debelle P, Davies L
Department of Community Medicine, University of Adelaide, South Australia.
J Infect Dis. 1990 Dec;162(6):1277-82. doi: 10.1093/infdis/162.6.1277.
A double-blind, placebo-controlled trial was conducted to study the effects of over-the-counter analgesic/antipyretic medications on virus shedding, immune response, and clinical status in the common cold. Sixty healthy volunteers were challenged intranasally with rhinovirus type 2 and randomized to one of four treatment arms: aspirin, acetaminophen, ibuprofen, or placebo. Fifty-six volunteers were successfully infected and shed virus on at least 4 days after challenge. Virus shedding, antibody levels, clinical symptoms and signs, and blood leukocyte levels were carefully monitored. Use of aspirin and acetaminophen was associated with suppression of serum neutralizing antibody response (P less than .05 vs. placebo) and increased nasal symptoms and signs (P less than .05 vs. placebo). A concomitant rise in circulating monocytes suggested that the suppression of antibody response may be mediated through drug effects on monocytes and/or mononuclear phagocytes. There were no significant differences in viral shedding among the four groups, but a trend toward longer duration of virus shedding was observed in the aspirin and acetaminophen groups.
进行了一项双盲、安慰剂对照试验，以研究非处方止痛/退烧药对普通感冒病毒排出、免疫反应及临床状况的影响。60名健康志愿者经鼻用2型鼻病毒攻击，并随机分为四个治疗组之一：阿司匹林组、对乙酰氨基酚组、布洛芬组或安慰剂组。56名志愿者成功感染，且在攻击后至少4天排出病毒。仔细监测了病毒排出、抗体水平、临床症状和体征以及血液白细胞水平。使用阿司匹林和对乙酰氨基酚与血清中和抗体反应受抑制（与安慰剂相比P<0.05）以及鼻部症状和体征增加（与安慰剂相比P<0.05）有关。循环单核细胞同时增多表明抗体反应受抑制可能是通过药物对单核细胞和/或单核吞噬细胞的作用介导的。四组之间病毒排出无显著差异，但在阿司匹林组和对乙酰氨基酚组中观察到病毒排出持续时间有延长的趋势。
