1st Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Maturitas. 2011 Sep;70(1):58-64. doi: 10.1016/j.maturitas.2011.06.003. Epub 2011 Jul 2.
The purpose of this study was to evaluate the impact of adherence to Mediterranean diet on serum uric acid (UA) levels in elderly individuals, without known cardiovascular disease.
During 2009, 281 females (75±6 years old) and 257 males (75±7 years old) permanent inhabitants of the island, were voluntarily enrolled. A diet score that assesses the inherent characteristics of the Mediterranean diet (MedDietScore, range 0-55) was applied. Serum levels of UA were determined using an enzymatic colorimetric test through the uricase-peroxidase method. Hyperuricaemia was defined as UA>7 mg/dL in males and 6 mg/dL in females.
Prevalence of hyperuricaemia was 34% in males and 25% in females (p=0.02). Mean level of adherence to the Mediterranean diet was 35±2. Linear regression analysis revealed that MedDietScore was inversely associated with UA levels (b±SE: -1.48±0.17, p<0.001) in the overall sample, after controlling for hypertension, hypercholesterolemia, diabetes mellitus, creatinine clearance, physical activity, and coffee consumption. When the analysis was stratified by gender, MedDietScore was inversely associated with UA levels in males (b±SE: -1.10±0.42, p=0.009), but not in females (b±SE: 0.04±0.41, p=0.92).
Another cardioprotective effect of Mediterranean diet was revealed, through the modification of UA levels in elderly individuals. The potential different effect size as regards the relationship between diet and UA levels between genders, deserves further investigation.
本研究旨在评估在无已知心血管疾病的老年人群中，坚持地中海饮食对血清尿酸（UA）水平的影响。
2009 年，我们招募了 281 名女性（75±6 岁）和 257 名男性（75±7 岁）作为常住居民。采用地中海饮食固有特征评估饮食评分（MedDietScore，范围 0-55）。采用尿酸酶-过氧化物酶法，通过酶比色试验检测血清 UA 水平。男性 UA>7mg/dL 和女性 UA>6mg/dL 定义为高尿酸血症。
男性高尿酸血症的患病率为 34%，女性为 25%（p=0.02）。地中海饮食的平均依从度为 35±2。线性回归分析显示，在控制高血压、高胆固醇血症、糖尿病、肌酐清除率、体力活动和咖啡摄入量后，MedDietScore 与 UA 水平呈负相关（b±SE：-1.48±0.17，p<0.001）。在按性别分层的分析中，MedDietScore 与男性 UA 水平呈负相关（b±SE：-1.10±0.42，p=0.009），但与女性 UA 水平无关（b±SE：0.04±0.41，p=0.92）。
通过改变老年人群的 UA 水平，揭示了地中海饮食的另一种心脏保护作用。饮食与 UA 水平之间的关系在性别方面可能存在不同的效果大小，值得进一步研究。
