Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Scand J Rheumatol. 2012;41(6):442-9. doi: 10.3109/03009742.2012.679964. Epub 2012 Jul 24.
The present study aimed to explore potential associations between adherence to a Mediterranean diet and serum uric acid (UA) levels.
The sample consisted of 2380 men and women free of cardiovascular or renal disease who participated in the ATTICA study. Dietary intake was assessed using a food frequency questionnaire (FFQ) and adherence to the Mediterranean diet was evaluated with the MedDietScore. Serum UA was measured and hyperuricaemia was defined as UA concentration > 7.0 mg/dL in men or > 6.0 mg/dL in women.
MedDietScore was inversely associated with UA levels (b-coefficient per quartile of the score = -0.07 ± 0.03, p = 0.02) independently of sex, presence of overweight, hypertension, or abnormal glucose metabolism, and alcohol or coffee intake. Those at the fourth quartile of MedDietScore had a 70% lower likelihood of having hyperuricaemia [odds ratio (OR) 0.30, 95% confidence interval (CI) 0.11-0.82] compared to those at the first quartile, after adjustment for several confounders. According to stratified analyses by sex, body mass index (BMI) status, hypertension, abnormal glucose, alcohol and coffee intake, the inverse association between serum UA and MedDietScore remained significant in women (b-coefficient = -0.194 ± 0.055, p < 0.001), overweight subjects (b-coefficient = -0.103 ± 0.047, p = 0.02), in those with normal glucose metabolism (b-coefficient = -0.074 ± 0.037, p = 0.04), and in those abstaining from alcohol (b-coefficient = -0.212 ± 0.073, p = 0.004) and coffee (b-coefficient = -0.221 ± 0.096, p = 0.02).
Adherence to the Mediterranean diet is associated with lower serum UA levels and lower likelihood of hyperuricaemia. These findings support a potential role of this dietary pattern in the prevention and treatment of hyperuricaemia and gout.
本研究旨在探讨地中海饮食与血清尿酸（UA）水平之间的潜在关联。
该研究的样本由 2380 名无心血管或肾脏疾病的男性和女性组成，他们参加了 ATTICA 研究。通过食物频率问卷（FFQ）评估饮食摄入情况，并使用 MedDietScore 评估地中海饮食的依从性。测量血清 UA，UA 浓度>男性 7.0mg/dL 或女性>6.0mg/dL 定义为高尿酸血症。
MedDietScore 与 UA 水平呈负相关（评分每四分位的系数=-0.07±0.03，p=0.02），独立于性别、超重、高血压或异常葡萄糖代谢以及酒精或咖啡摄入。与第一四分位相比，MedDietScore 处于第四四分位的人群发生高尿酸血症的可能性低 70%[比值比（OR）0.30，95%置信区间（CI）0.11-0.82]，调整了多个混杂因素后结果仍然成立。根据性别、体重指数（BMI）状态、高血压、异常葡萄糖、酒精和咖啡摄入的分层分析，血清 UA 与 MedDietScore 之间的负相关在女性（系数=-0.194±0.055，p<0.001）、超重者（系数=-0.103±0.047，p=0.02）、血糖正常者（系数=-0.074±0.037，p=0.04）和不饮酒者（系数=-0.212±0.073，p=0.004）以及不喝咖啡者（系数=-0.221±0.096，p=0.02）中仍然显著。
地中海饮食的依从性与较低的血清 UA 水平和较低的高尿酸血症发生率相关。这些发现支持这种饮食模式在预防和治疗高尿酸血症和痛风方面的潜在作用。
