Department of Infectious Disease, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Cleve Clin J Med. 2011 Jul;78(7):465-71. doi: 10.3949/ccjm.78a.10168.
Because a significant proportion of Staphylococcus aureus strains as well as most coagulase-negative staphylococci are resistant to penicillin and semisynthetic beta-lactam drugs, the need for vancomycin and related antibiotics has never been greater. Effective use of vancomycin requires knowledge of dosing parameters and selection of target trough levels appropriate to the specific infection and to the pathogen being treated. For clinicians, it is vital to remain up-to-date with evolving definitions for vancomycin susceptibility, with new interpretations of efficacy, and with information on toxicity.
由于相当一部分金黄色葡萄球菌菌株以及大多数凝固酶阴性葡萄球菌对青霉素和半合成β-内酰胺类药物具有耐药性，万古霉素和相关抗生素的需求从未如此之大。有效使用万古霉素需要了解剂量参数，并选择适合特定感染和所治疗病原体的目标谷浓度。对于临床医生来说，及时了解万古霉素敏感性的不断变化的定义、疗效的新解释以及关于毒性的信息至关重要。
