苯乙烯暴露与癌症风险。
Styrene exposure and risk of cancer.
机构信息
National Institute of Environmental Health Sciences, Research Triangle Park, 111 T.W.Alexander Drive, NC 27709, USA.
出版信息
Mutagenesis. 2011 Sep;26(5):583-4. doi: 10.1093/mutage/ger033. Epub 2011 Jul 1.
Abstract
Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. Subsequent epidemiologic studies found styrene workers had increased mortality or incidences of lymphohematopoietic cancers (leukaemia or lymphoma or all), with suggestive evidence for pancreatic and esophageal tumours. No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. Both are genotoxic and form DNA adducts in humans.
摘要
苯乙烯广泛用于合成橡胶、树脂、聚酯和塑料的制造。苯乙烯和主要代谢物苯乙烯-7,8-氧化物具有遗传毒性和致癌性。长期化学致癌生物测定表明，苯乙烯导致几种品系的小鼠肺癌和大鼠乳腺癌，以及苯乙烯-7,8-氧化物导致大鼠和小鼠的前胃肿瘤和小鼠的肝脏肿瘤。随后的流行病学研究发现，苯乙烯工人的死亡率或淋巴血液系统癌症（白血病或淋巴瘤或两者）发病率增加，提示胰腺和食管肿瘤的证据。尽管苯乙烯-7,8-氧化物是苯乙烯的主要和活性环氧化物代谢物，但目前尚无足够的人类研究。两者均具有遗传毒性，并在人体中形成 DNA 加合物。
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