Nat Cell Biol. 2011 Jul 3;13(8):884-6. doi: 10.1038/ncb2300.
The retromer complex coordinates retrograde transport of cargo proteins between endosomes and the trans-Golgi network. The sorting nexin SNX3 is required for the retrograde trafficking of Wntless, but not of other retrograde cargo proteins, revealing that the cargo specificity of retromer is provided by the sorting nexins.
回转体复合物协调 cargo 蛋白在内体和反式高尔基体网络之间的逆行运输。分选连接蛋白 SNX3 是 Wntless 逆行运输所必需的,但不是其他逆行 cargo 蛋白所必需的,这表明回转体的 cargo 特异性是由分选连接蛋白提供的。