Langford Katherine H, Reid Malcolm, Thomas Kevin V
Norwegian Institute for Water Research (NIVA), Gaustadallèen 21, 0349, Oslo, Norway.
J Environ Monit. 2011 Aug;13(8):2284-91. doi: 10.1039/c1em10260e. Epub 2011 Jul 4.
A robust multi-residue method was developed for the analysis of a selection of pharmaceutical compounds, illicit drugs and personal care product bactericides in sediments and sludges. Human pharmaceuticals were selected for analysis in Scottish sewage sludge and freshwater sediments based on prescription, physico-chemical and occurrence data. The method was suitable for the analysis of the selected illicit drugs amphetamine, benzoylecgonine, cocaine, and methamphetamine, the pharmaceuticals atenolol, bendroflumethiazide, carbamazepine, citalopram, diclofenac, fluoxetine, ibuprofen, and salbutamol, and the bactericides triclosan and triclocarban in sewage sludge and freshwater sediment. The method provided an overall recovery of between 56 and 128%, RSDs of between 2 and 19% and LODs of between 1 and 50 ng g(-1). Using the methodology the human pharmaceuticals atenolol, carbamazepine and citalopram and the bactericides triclosan and triclocarban were detected in Scottish sewage sludge. The illicit drugs cocaine, its metabolite benzoylecgonine, amphetamine and methamphetamine were not detected in any of the samples analysed. Triclosan and triclocarban were present at the highest concentrations with triclocarban detected in all but one sample and showing a pattern of co-occurrence in both sludge and sediment samples.
开发了一种稳健的多残留方法，用于分析沉积物和污泥中的多种药物化合物、非法药物和个人护理产品杀菌剂。根据处方、物理化学和出现数据，选择了人类药物在苏格兰污水污泥和淡水沉积物中进行分析。该方法适用于分析选定的非法药物苯丙胺、苯甲酰芽子碱、可卡因和甲基苯丙胺、药物阿替洛尔、苄氟噻嗪、卡马西平、西酞普兰、双氯芬酸、氟西汀、布洛芬和沙丁胺醇，以及污水污泥和淡水沉积物中的杀菌剂三氯生和三氯卡班。该方法的总体回收率在56%至128%之间，相对标准偏差在2%至19%之间，检测限在1至50 ng g(-1)之间。使用该方法在苏格兰污水污泥中检测到了人类药物阿替洛尔、卡马西平和西酞普兰以及杀菌剂三氯生和三氯卡班。在所分析的任何样品中均未检测到非法药物可卡因及其代谢物苯甲酰芽子碱、苯丙胺和甲基苯丙胺。三氯生和三氯卡班的浓度最高，除一个样品外，所有样品中均检测到三氯卡班，并且在污泥和沉积物样品中均呈现出共现模式。
