Lekic Tim, Ostrowski Robert P, Suzuki Hidenori, Manaenko Anatol, Rolland William, Fathali Nancy, Tang Jiping, Zhang John H
Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, CA 92354, USA.
Acta Neurochir Suppl. 2011;111:37-41. doi: 10.1007/978-3-7091-0693-8_7.
Intracerebral hemorrhage (ICH) is one of the most common causes of maternal deaths related to the postpartum period. This is a devastating form of stroke for which there is no available treatment. Although premenopausal females tend to have better outcomes after most forms of brain injury, the effects of pregnancy and child birth lead to wide maternal physiological changes that may predispose the mother to an increased risk for stroke and greater initial injury.
Three different doses of collagenase were used to generate models of mild, moderate and severe cerebellar hemorrhage in postpartum female and male control rats. Brain water, blood-brain barrier rupture, hematoma size and neurological evaluations were performed 24 h later.
Postpartum female rats had worsened brain water, blood-brain barrier rupture, hematoma size and neurological evaluations compared to their male counterparts.
The postpartum state reverses the cytoprotective effects commonly associated with the hormonal neuroprotection of (premenopausal) female gender, and leads to greater initial injury and worsened neurological function after cerebellar hemorrhage. This experimental model can be used for the study of future treatment strategies after postpartum brain hemorrhage, to gain a better understanding of the mechanistic basis for stroke in this important patient subpopulation.
脑出血（ICH）是产后孕产妇死亡的最常见原因之一。这是一种毁灭性的中风形式，目前尚无有效治疗方法。尽管绝经前女性在大多数形式的脑损伤后往往预后较好，但怀孕和分娩的影响会导致孕产妇生理发生广泛变化，这可能使母亲更容易发生中风且初始损伤更大。
使用三种不同剂量的胶原酶在产后雌性和雄性对照大鼠中建立轻度、中度和重度小脑出血模型。24小时后进行脑含水量、血脑屏障破裂、血肿大小和神经功能评估。
与雄性大鼠相比，产后雌性大鼠的脑含水量、血脑屏障破裂、血肿大小和神经功能评估结果更差。
产后状态逆转了通常与（绝经前）女性激素神经保护相关的细胞保护作用，并导致小脑出血后初始损伤更大、神经功能恶化。该实验模型可用于研究产后脑出血的未来治疗策略，以更好地理解这一重要患者亚群中风的机制基础。
