Chen Zheng, Xi Guohua, Mao Ying, Keep Richard F, Hua Ya
Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109-2200, USA.
Acta Neurochir Suppl. 2011;111:289-93. doi: 10.1007/978-3-7091-0693-8_48.
Studies have shown that progesterone reduces brain injury, whereas testosterone increases lesion size after ischemic stroke. This study examined the effects of progesterone and testosterone on intracerebral hemorrhage (ICH)-induced brain injury. Male Sprague-Dawley rats received an injection of 100 μL autologous whole blood into the right basal ganglia. Progesterone (16 mg/kg), testosterone (15 mg/kg) or vehicle was given intraperitoneally 2 h after ICH. Behavioral tests were performed, and the rats were killed after 24 h for brain edema measurement. Perihematomal brain edema was reduced in progesterone-treated rats compared to vehicle-treated rats (p<0.05). Progesterone also improved functional outcome following ICH (p<0.05). Testosterone treatment did not affect perihematomal edema formation, but resulted in lower forelimb placing score (p<0.05). In conclusion, progesterone can reduce brain edema and improve functional outcome, whereas testosterone may have a deleterious effect after ICH in male rats.
研究表明，黄体酮可减轻脑损伤，而睾酮会增加缺血性中风后的损伤面积。本研究检测了黄体酮和睾酮对脑出血（ICH）所致脑损伤的影响。雄性斯普拉格-道利大鼠右侧基底节注射100 μL自体全血。脑出血后2小时腹腔注射黄体酮（16 mg/kg）、睾酮（15 mg/kg）或赋形剂。进行行为测试，24小时后处死大鼠以测量脑水肿。与赋形剂处理的大鼠相比，黄体酮处理的大鼠血肿周围脑水肿减轻（p<0.05）。黄体酮还改善了脑出血后的功能结局（p<0.05）。睾酮处理不影响血肿周围水肿形成，但导致前肢放置评分降低（p<0.05）。总之，黄体酮可减轻脑水肿并改善功能结局，而睾酮在雄性大鼠脑出血后可能具有有害作用。
