State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, 200031 Shanghai, China.
Curr Top Microbiol Immunol. 2012;353:111-21. doi: 10.1007/82_2011_149.
Hundreds of human genes express mRNAs that contain inverted repeat sequences within their 3'-UTRs. When expressed, these sequences can be promiscuously edited by ADAR enzymes, leading to the retention of mRNAs in nuclear paraspeckles. Here we discuss how this retention system can be used to regulate gene expression.
数百个人类基因表达的 mRNAs 在其 3'-UTRs 内含有反向重复序列。当这些序列被表达时，它们可以被 ADAR 酶随意编辑，导致 mRNAs 保留在核斑点中。在这里，我们讨论了如何利用这种保留系统来调节基因表达。
