Department of Psychiatry at the VA Boston Healthcare System, Harvard Medical School, Brockton, MA, USA.
Brain Imaging Behav. 2011 Dec;5(4):252-61. doi: 10.1007/s11682-011-9129-0.
The current report used structural magnetic resonance imaging (MRI) to objectively measure olfactory bulb volume and olfactory sulcal depth in patients diagnosed with chronic schizophrenia and healthy controls. Additional measures were obtained to assess olfactory function. The olfactory bulb and sulcus were manually traced on structural 3T MRIs for 25 right-handed male patients diagnosed with chronic schizophrenia and 25 matched male healthy controls. A sub-set of subjects received the University of Pennsylvania Smell Identification Test (UPSIT). Olfactory bulb volume was significantly decreased in patients with schizophrenia compared to healthy controls, as was their performance on the UPSIT. Additionally, a positive correlation was seen in patients between right bulb volume and UPSIT scores. Overall, our findings support earlier research studies showing morphometric and functional changes in the olfactory system in patients with schizophrenia.
本报告使用结构磁共振成像（MRI）客观测量了被诊断为慢性精神分裂症的患者和健康对照者的嗅球体积和嗅沟深度。还获得了其他措施来评估嗅觉功能。在 25 名被诊断为慢性精神分裂症的右利手男性患者和 25 名匹配的男性健康对照者的结构 3T MRI 上手动追踪嗅球和嗅沟。一组受试者接受了宾夕法尼亚大学嗅觉识别测试（UPSIT）。与健康对照组相比，精神分裂症患者的嗅球体积明显减小，他们在 UPSIT 上的表现也较差。此外，患者的右侧嗅球体积与 UPSIT 评分呈正相关。总的来说，我们的发现支持了早期的研究，表明精神分裂症患者的嗅觉系统存在形态和功能变化。
