Kapıcı Yaşar, Koparal Mehtap, Aslan Sefer
Department of Psychiatry, Adana 5 Ocak State Hospital, Adana, Turkey.
Department of Otolaryngology, Adıyaman University Faculty of Medicine, Adıyaman, Turkey.
Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):1580-1585. doi: 10.1007/s12070-023-04363-3. Epub 2023 Nov 25.
Nasal mucociliary clearance time (NMCT) is prolonged in patients with olfactory disorders. It is essential to differentially diagnose conductive and neural olfactory disorders. Here, we used the mucociliary clearance test to investigate a disease associated with neural olfactory disorders, i.e. schizophrenia. Data on age, gender, and duration of disease were collected. The study involved 56 schizophrenia patients and 56 healthy controls. There was no significant difference between the groups regarding age and gender (p = 0.459 and p = 0.768 respectively). Mean NMCT of patients with schizophrenia was 13.82 ± 3.22 min and mean NMCT of healthy controls was 10.15 ± 2.94 min. There was significant difference between the groups regarding NMCT (p < 0.001). In the patient group, there was a significant positive correlation between duration of disease, age, and NMCT (Pearson r = 0.286, p = 0.032, and Pearson r = 0.522, p < 0.001 respectively). This study has shown a prolonged NMCT in patients with schizophrenia compared to the healthy control group.
嗅觉障碍患者的鼻黏液纤毛清除时间（NMCT）会延长。鉴别诊断传导性和神经性嗅觉障碍至关重要。在此，我们使用黏液纤毛清除试验来研究一种与神经性嗅觉障碍相关的疾病，即精神分裂症。收集了年龄、性别和病程的数据。该研究纳入了56例精神分裂症患者和56例健康对照者。两组在年龄和性别方面无显著差异（分别为p = 0.459和p = 0.768）。精神分裂症患者的平均NMCT为13.82±3.22分钟，健康对照者的平均NMCT为10.15±2.94分钟。两组在NMCT方面存在显著差异（p < 0.001）。在患者组中，病程、年龄与NMCT之间存在显著正相关（Pearson相关系数r分别为0.286，p = 0.032；以及Pearson相关系数r为0.522，p < 0.001）。本研究表明，与健康对照组相比，精神分裂症患者的NMCT延长。
