School of Health Sciences, Queen Margaret University, Musselburgh, Edinburgh, Scotland, UK.
J Membr Biol. 2011 Jul;242(2):53-67. doi: 10.1007/s00232-011-9376-4. Epub 2011 Jul 5.
Changes in the regulation of potassium channels are increasingly implicated in the altered activity of breast cancer cells. Increased or reduced expression of a number of K(+) channels have been identified in numerous breast cancer cell lines and cancerous tissue biopsy samples, compared to normal tissue, and are associated with tumor formation and spread, enhanced levels of proliferation, and resistance to apoptotic stimuli. Through knockout or silencing of K(+) channel genes, and use of specific or more broad pharmacologic K(+) channel blockers, the growth of numerous cell lines, including breast cancer cells, has been modified. In this manner it has been proposed that in MCF7 breast cancer cells proliferation appears to be regulated by the activity of a number of K(+) channels, including the Ca(2+) activated K(+) channels, and the voltage-gated K(+) channels hEAG and K(v)1.1. The effect of phytoestrogens on K(+) channels has not been extensively studied but yields some interesting results. In a number of cell lines the phytoestrogen genistein inhibits K(+) current through several channels including K(v)1.3 and hERG. Where it has been used, structurally similar daidzein has little or no effect on K(+) channel activity. Since many K(+) channels have roles in proliferation and apoptosis in breast cancer cells, the impact of K(+) channel regulation by phytoestrogens is of potentially great relevance.
钾通道调节的变化越来越多地与乳腺癌细胞活性的改变有关。与正常组织相比，许多乳腺癌细胞系和癌组织活检样本中发现了一些 K(+)通道的表达增加或减少，并且与肿瘤形成和扩散、增殖水平增强以及对凋亡刺激的抗性有关。通过敲除或沉默 K(+)通道基因，以及使用特定或更广泛的药理学 K(+)通道阻滞剂，可以改变许多细胞系的生长，包括乳腺癌细胞。通过这种方式，有人提出 MCF7 乳腺癌细胞的增殖似乎受多种 K(+)通道的活性调节，包括 Ca(2+)激活的 K(+)通道和电压门控的 K(+)通道 hEAG 和 K(v)1.1。植物雌激素对 K(+)通道的影响尚未得到广泛研究，但产生了一些有趣的结果。在一些细胞系中，植物雌激素染料木黄酮抑制包括 K(v)1.3 和 hERG 在内的几种通道的 K(+)电流。在使用时，结构相似的大豆苷元对 K(+)通道活性几乎没有影响或没有影响。由于许多 K(+)通道在乳腺癌细胞的增殖和凋亡中起作用，因此植物雌激素对 K(+)通道调节的影响具有潜在的重要意义。
