Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Cancer Causes Control. 2011 Oct;22(10):1375-82. doi: 10.1007/s10552-011-9810-z. Epub 2011 Jul 5.
To prospectively evaluate the associations of dietary calcium and magnesium intake with cancer incidence and mortality, data of 24,323 participants of the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg), who were aged 35-64 years and cancer-free at recruitment (1994-1998), were analyzed using multivariate Cox regression models. After an average follow-up time of 11 years, 2,050 incident cancers were diagnosed and 513 cancer deaths occurred. Dietary calcium intake was inversely but not statistically significantly associated with colorectal cancer risk (hazard ratio [HR] for per 100 mg increase in intake: 0.95; 95% confidence interval [CI]: 0.88, 1.02) and lung cancer risk (HR for per 100 mg increase in intake: 0.94; 95% CI: 0.87, 1.02). No statistically significant associations were observed between dietary calcium intake and site-specific or overall cancer incidence or mortality. Dietary magnesium intake was not statistically significantly associated with any of the investigated outcomes. This prospective cohort study provides no strong evidence to support that high dietary calcium and magnesium intake in the intake range observed in a German population may reduce cancer incidence or mortality.
为前瞻性评估膳食钙和镁的摄入量与癌症发病率和死亡率之间的关系，对欧洲癌症前瞻性调查和营养研究（EPIC-Heidelberg）海德堡队列的 24323 名参与者的数据进行了分析，这些参与者年龄在 35-64 岁之间，在招募时无癌症（1994-1998 年）。使用多变量 Cox 回归模型分析数据。在平均随访 11 年后，诊断出 2050 例新发癌症，513 例癌症死亡。膳食钙的摄入量与结直肠癌风险呈负相关，但无统计学意义（每增加 100mg 摄入量的风险比 [HR]：0.95；95%置信区间 [CI]：0.88，1.02）和肺癌风险（每增加 100mg 摄入量的 HR：0.94；95%CI：0.87，1.02）。膳食钙摄入量与特定部位或总体癌症发病率或死亡率之间无统计学显著相关性。膳食镁的摄入量与任何研究结果均无统计学显著相关性。这项前瞻性队列研究没有强有力的证据表明，在德国人群观察到的摄入量范围内，高膳食钙和镁的摄入量可能降低癌症的发病率或死亡率。
