Institut Català de Nanotecnologia (ICN), Campus UAB, 08193 Bellaterra, Barcelona, Spain.
Langmuir. 2011 Sep 6;27(17):11098-105. doi: 10.1021/la201938u. Epub 2011 Jul 29.
Monodisperse citrate-stabilized gold nanoparticles with a uniform quasi-spherical shape of up to ∼200 nm and a narrow size distribution were synthesized following a kinetically controlled seeded growth strategy via the reduction of HAuCl(4) by sodium citrate. The inhibition of any secondary nucleation during homogeneous growth was controlled by adjusting the reaction conditions: temperature, gold precursor to seed particle concentration, and pH. This method presents improved results regarding the traditional Frens method in several aspects: (i) it produces particles of higher monodispersity; (ii) it allows better control of the gold nanoparticle size and size distribution; and (iii) it leads to higher concentrations. Gold nanoparticles synthesized following this method can be further functionalized with a wide variety of molecules, hence this method appears to be a promising candidate for application in the fields of biomedicine, photonics, and electronics, among others.
采用动力学控制的种子生长策略，通过柠檬酸钠还原 HAuCl(4)，合成了具有高达约 200nm 的均匀准球形形状和窄粒径分布的单分散柠檬酸稳定的金纳米粒子。通过调节反应条件（温度、金前驱体与种子颗粒浓度和 pH 值）来控制均相生长过程中任何二次成核的抑制。与传统的 Frens 方法相比，该方法在几个方面具有改进的结果：（i）它产生更高单分散性的颗粒；（ii）它可以更好地控制金纳米颗粒的尺寸和粒径分布；（iii）它导致更高的浓度。通过这种方法合成的金纳米粒子可以进一步功能化，具有多种分子，因此该方法似乎是在生物医药、光子学和电子学等领域应用的有前途的候选者。
