Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
Psychophysiology. 2011 Nov;48(11):1572-1577. doi: 10.1111/j.1469-8986.2011.01221.x. Epub 2011 Jul 5.
The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of cholesterol and CYP46 genotypes on cognitive event-related potentials (ERPs). The subjects with a high low-density lipoprotein cholesterol (LDL-C) level displayed significantly lower amplitude ERPs, although the CASI scores showed no difference. There was no association between the CYP46 genotypes, CASI scores, cholesterol levels, and measures of ERPs. No interaction between LDL-C level and CYP46 genotypes was noted. The LDL-C level is an independent predictor of low P300 amplitude. Prevention and treatment of high cholesterol may be of potential benefit in reducing cognitive impairment.
胆固醇和 CYP46 基因型的综合作用对认知能力下降的风险需要确定。使用认知能力筛查工具 (CASI)，招募了 145 名心理健康的中老年成年人，以调查胆固醇和 CYP46 基因型对认知事件相关电位 (ERPs) 的影响。尽管 CASI 评分没有差异，但 LDL-C 水平高的受试者的 ERP 振幅明显较低。CYP46 基因型、CASI 评分、胆固醇水平和 ERP 测量之间没有关联。未观察到 LDL-C 水平和 CYP46 基因型之间的相互作用。LDL-C 水平是 P300 振幅降低的独立预测因子。预防和治疗高胆固醇可能有助于降低认知障碍。
