减重手术的机制能否为新型疗法提供关键？彭宁顿科学研讨会报告。
Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium.
机构信息
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
出版信息
Obes Rev. 2011 Nov;12(11):984-94. doi: 10.1111/j.1467-789X.2011.00902.x. Epub 2011 Jul 6.
Abstract
Bariatric surgery is the most effective method for promoting dramatic and durable weight loss in morbidly obese subjects. Furthermore, type 2 diabetes is resolved in over 80% of patients. The mechanisms behind the amelioration in metabolic abnormalities are largely unknown but may be due to changes in energy metabolism, gut peptides and food preference. The goal of this meeting was to review the latest research to better understand the mechanisms behind the 'magic' of bariatric surgery. Replication of these effects in a non-surgical manner remains one of the ultimate challenges for the treatment of obesity and diabetes. Promising data on energy metabolism, gastrointestinal physiology, hedonic response and food intake were reviewed and discussed.
摘要
减重手术是促进病态肥胖患者显著且持久减肥的最有效方法。此外，80%以上的 2 型糖尿病患者的病情得到缓解。代谢异常改善背后的机制在很大程度上尚不清楚，但可能是由于能量代谢、肠道肽和食物偏好的变化。本次会议的目的是回顾最新的研究成果，以更好地了解减重手术“魔力”背后的机制。以非手术方式复制这些效果仍然是治疗肥胖和糖尿病的终极挑战之一。会上回顾和讨论了有关能量代谢、胃肠道生理学、享乐反应和食物摄入的有希望的数据。
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本文引用的文献
1
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Ann Surg. 2011 Mar;253(3):502-7. doi: 10.1097/SLA.0b013e318203a289.
2
Early clinical studies with liraglutide.利拉鲁肽的早期临床研究。
Int J Clin Pract Suppl. 2010 Oct(167):12-20. doi: 10.1111/j.1742-1241.2010.02500.x.
3
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.高脂饮食：细菌相互作用促进肠道炎症，这种炎症先于肥胖和胰岛素抵抗发生，并与肥胖和胰岛素抵抗相关。
PLoS One. 2010 Aug 16;5(8):e12191. doi: 10.1371/journal.pone.0012191.
4
Medication utilization and annual health care costs in patients with type 2 diabetes mellitus before and after bariatric surgery.肥胖症手术后2型糖尿病患者的药物使用情况及年度医疗费用
Arch Surg. 2010 Aug;145(8):726-31. doi: 10.1001/archsurg.2010.150.
5
Gastric bypass surgery alters behavioral and neural taste functions for sweet taste in obese rats.胃旁路手术改变肥胖大鼠对甜味的行为和神经味觉功能。
Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G967-79. doi: 10.1152/ajpgi.00070.2010. Epub 2010 Jul 15.
6
Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities.回肠间置术后肠道适应性增加胆汁酸循环，预防肥胖相关合并症。
Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G652-60. doi: 10.1152/ajpgi.00221.2010. Epub 2010 Jul 1.
7
Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation.大鼠高脂肪饮食诱导肥胖的倾向与肠道微生物群和肠道炎症的变化有关。
Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G440-8. doi: 10.1152/ajpgi.00098.2010. Epub 2010 May 27.
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Physiol Behav. 2010 Jul 14;100(5):549-59. doi: 10.1016/j.physbeh.2010.04.032. Epub 2010 May 8.
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Trends Endocrinol Metab. 2010 Aug;21(8):473-9. doi: 10.1016/j.tem.2010.03.006. Epub 2010 Apr 21.
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