Vincent R P, le Roux C W
Department of Chemical Pathology, King's College Hospital, London, UK.
Clin Endocrinol (Oxf). 2008 Aug;69(2):173-9. doi: 10.1111/j.1365-2265.2007.03164.x. Epub 2007 Dec 20.
Bariatric surgery is one of the most effective treatments for achieving long-term weight loss in morbidly obese patients. Bariatric surgery causes weight loss through substantial decline of hunger and increased satiety. Recently our understanding of neuroendocrine regulation of food intake and weight gain, especially regarding the role of gut hormones, has significantly increased. The changes in these hormones following bariatric surgery can partly explain the mechanism behind weight loss achieved through these procedures. In this paper, we review the effect bariatric procedures have on different gut hormone levels and how they in turn can alter the complex neuroendocrine regulation of energy homeostasis.
减肥手术是病态肥胖患者实现长期体重减轻最有效的治疗方法之一。减肥手术通过大幅降低饥饿感和增加饱腹感来实现体重减轻。最近，我们对食物摄入和体重增加的神经内分泌调节，尤其是肠道激素的作用的理解有了显著提高。减肥手术后这些激素的变化可以部分解释通过这些手术实现体重减轻的背后机制。在本文中，我们综述了减肥手术对不同肠道激素水平的影响，以及它们如何反过来改变能量稳态的复杂神经内分泌调节。
