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波多黎各成年人肥胖指数与心血管代谢危险因素的相关性。

Association between adiposity indices and cardiometabolic risk factors among adults living in Puerto Rico.

机构信息

Nutrition Program, Department of Human Development, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, PO Box 365067, San Juan, PR.

出版信息

Public Health Nutr. 2011 Oct;14(10):1714-23. doi: 10.1017/S1368980011000796. Epub 2011 May 24.

DOI:10.1017/S1368980011000796
PMID:21729484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3438511/
Abstract

OBJECTIVE

To compare the general adiposity index (BMI) with abdominal obesity indices (waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR)) in order to examine the best predictor of cardiometabolic risk factors among Hispanics living in Puerto Rico.

DESIGN

Secondary analysis of measurements taken from a representative sample of adults. Logistic regression models (prevalence odds ratios (POR)), partial Pearson's correlations (controlling for age and sex) and receiver-operating characteristic (ROC) curves were calculated between indices of obesity (BMI, WC, WHR and WHtR) and blood pressure, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), total cholesterol (TC):HDL-C, TAG, fasting blood glucose, glycosylated Hb, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and an aggregated measure of cardiometabolic risk.

SETTING

Household study conducted between 2005 and 2007 in the San Juan Metropolitan Area in Puerto Rico.

SUBJECTS

A representative sample of 858 non-institutionalized adults.

RESULTS

All four obesity indices significantly correlated with the cardiometabolic risk factors. WHtR had the highest POR for high TC:HDL-C, blood pressure, hs-CRP, fibrinogen and PAI-1; WC had the highest POR for low HDL-C and high LDL-C and fasting blood glucose; WHR had the highest POR for overall cardiometabolic risk, TAG and glycosylated Hb. BMI had the lowest POR for most risk factors and smallest ROC curve for overall cardiometabolic risk.

CONCLUSIONS

The findings of the study suggest that general adiposity and abdominal adiposity are both associated with cardiometabolic risk in this population, although WC, WHR and WHtR appear to be slightly better predictors than BMI.

摘要

目的

比较通用肥胖指数(BMI)与腹部肥胖指数(腰围(WC)、腰臀比(WHR)和腰高比(WHtR)),以检验这些指数在评估波多黎各居住的西班牙裔人心血管代谢危险因素方面的最佳预测能力。

设计

对成年人代表性样本的测量值进行二次分析。计算肥胖指数(BMI、WC、WHR 和 WHtR)与血压、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇:HDL-C、甘油三酯(TAG)、空腹血糖、糖化血红蛋白、高敏 C 反应蛋白(hs-CRP)、纤维蛋白原、纤溶酶原激活物抑制剂-1(PAI-1)以及心血管代谢风险综合指标之间的逻辑回归模型(患病率比值比(POR))、偏 Pearson 相关系数(控制年龄和性别)和接收者操作特征(ROC)曲线。

地点

2005 年至 2007 年在波多黎各圣胡安大都市区进行的家庭研究。

对象

858 名非住院成年人的代表性样本。

结果

所有四个肥胖指数均与心血管代谢危险因素显著相关。WHtR 对高 TC:HDL-C、血压、hs-CRP、纤维蛋白原和 PAI-1 的 POR 最高;WC 对低 HDL-C 和高 LDL-C 以及空腹血糖的 POR 最高;WHR 对总体心血管代谢风险、TAG 和糖化血红蛋白的 POR 最高。BMI 对大多数危险因素的 POR 最低,对总体心血管代谢风险的 ROC 曲线最小。

结论

研究结果表明,在该人群中,全身性肥胖和腹部肥胖均与心血管代谢风险相关,尽管 WC、WHR 和 WHtR 似乎略优于 BMI。

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