Maes M, Vandewoude M, Schotte C, Martin M, Blockx P
Department of Psychiatry, University Hospital of Antwerp, Belgium.
Psychol Med. 1990 Aug;20(3):493-9. doi: 10.1017/s0033291700017001.
In the past some workers have reported positive relationships between indices of noradrenaline activity and measures of hypothalamic-pituitary-adrenal (HPA)-axis function. In order to investigate these relations, the authors measured noradrenaline, adrenaline and vanillylmandelic acid (VMA) in 24 h urine samples of 72 depressed females. Serum adrenocorticotrophic hormone (ACTH) and cortisol concentrations were determined before and after administration of 1 mg of dexamethasone. Cortisol non-suppressors exhibited a significantly higher noradrenaline, adrenaline and VMA excretion as compared to cortisol suppressors. We determined significantly positive correlations between the postdexamethasone cortisol values and the excretion rates of noradrenaline and VMA. These indices of noradrenaline activity correlated neither with the baseline cortisol and ACTH nor with the postdexamethasone ACTH values.
过去，一些研究人员报告了去甲肾上腺素活性指标与下丘脑 - 垂体 - 肾上腺（HPA）轴功能指标之间存在正相关关系。为了研究这些关系，作者检测了72名抑郁女性24小时尿液样本中的去甲肾上腺素、肾上腺素和香草扁桃酸（VMA）。在给予1毫克地塞米松前后，测定血清促肾上腺皮质激素（ACTH）和皮质醇浓度。与皮质醇抑制者相比，皮质醇非抑制者的去甲肾上腺素、肾上腺素和VMA排泄量显著更高。我们确定地塞米松后皮质醇值与去甲肾上腺素和VMA排泄率之间存在显著正相关。这些去甲肾上腺素活性指标与基线皮质醇和ACTH均无相关性，也与地塞米松后ACTH值无关。
