抑郁症患者和对照组的尿游离皮质醇：与去甲肾上腺素能功能的尿指标的关系。
Urinary-free cortisol in depressed patients and controls: relationship to urinary indices of noradrenergic function.
作者信息
Roy A, Linnoila M, Karoum F, Pickar D
机构信息
Section of Clinical Studies, National Institute of Mental Health, Bethesda, MD 20892.
出版信息
Psychol Med. 1988 Feb;18(1):93-8. doi: 10.1017/s0033291700001926.
We measured urinary outputs of urinary-free cortisol in 28 medication-free depressed patients and 32 normal controls. Depressed patients had significantly greater urinary outputs of urinary-free cortisol than controls. Also, there were significant correlations among depressed patients, but not among controls, between urinary-free cortisol and urinary outputs of norepinephrine and its metabolite vanillylmandelic acid (VMA). These urinary data extend recent findings suggesting that dysregulation of both the hypothalamic-pituitary-adrenal axis and noradrenergic system occur together in depression.
我们测量了28名未服用药物的抑郁症患者和32名正常对照者的尿游离皮质醇排泄量。抑郁症患者的尿游离皮质醇排泄量显著高于对照组。此外，在抑郁症患者中，尿游离皮质醇与去甲肾上腺素及其代谢产物香草扁桃酸（VMA）的排泄量之间存在显著相关性，而在对照组中则不存在。这些尿液数据扩展了最近的研究结果，表明下丘脑-垂体-肾上腺轴和去甲肾上腺素能系统的失调在抑郁症中共同存在。
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