Gupta Money, Mahajan J K, Bawa Monika, Rao K L N
Department of Pediatric Surgery, Advanced Pediatrics Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
J Indian Assoc Pediatr Surg. 2011 Apr;16(2):50-3. doi: 10.4103/0971-9261.78130.
A significant number of esophageal atresia and tracheoesophageal fistula patients have long gaps and a high propensity to leak. Anastomotic leak in esophageal atresia is associated with a significant morbidity and mortality.
In a prospective randomized trial, we analyzed the risk factors leading to anastomotic dehiscence and studied the effect of pleural wrap as an additional vascular cover around the esophageal anastomosis.
Forty patients were divided into two groups A and B randomly. In 20 patients of group A, pleural wrap was utilized for covering the anastomosis and in 20 patients of group B, no such wrap was utilized.
Both the groups were comparable regarding age, sex, weight, gap length, tension at anastomosis and the hospital stay. The overall leak rate was 25% (10/40) in both the groups. The leak rate was not significantly different in two groups whenever a gap length was less than 2 cm or more than 3 cm. However, for a gap length of 2-3 cm, the leak rate in group A was 18% (2/11) and in group B was 50% (4/8) (P = 0.05). Thirty percent (3/10) of patients, whose anastomosis was under tension, leaked in group A as compared to 75% (6/8) in group B patients (P = 0.001).
Use of pleural wrap was associated with less anastomotic dehiscence in patients with moderate gap esophageal atresia (2-3 cm) especially when the anastomosis was under tension.
大量食管闭锁及食管气管瘘患者存在长间隙且吻合口漏的倾向较高。食管闭锁患者的吻合口漏与显著的发病率和死亡率相关。
在一项前瞻性随机试验中,我们分析了导致吻合口裂开的危险因素,并研究了胸膜包裹作为食管吻合口周围额外血管覆盖物的效果。
40例患者随机分为A、B两组。A组20例患者采用胸膜包裹覆盖吻合口,B组20例患者未采用此类包裹。
两组在年龄、性别、体重、间隙长度、吻合口张力及住院时间方面具有可比性。两组的总体漏率均为25%(10/40)。当间隙长度小于2 cm或大于3 cm时,两组的漏率无显著差异。然而,对于间隙长度为2 - 3 cm的情况,A组的漏率为18%(2/11),B组为50%(4/8)(P = 0.05)。A组吻合口有张力的患者中30%(3/10)发生漏,而B组患者中这一比例为75%(6/8)(P = 0.001)。
对于中度间隙性食管闭锁(2 - 3 cm)患者,尤其是吻合口有张力时,使用胸膜包裹可减少吻合口裂开。