Ebert S, Schweiger K-P, Nau R
Department of Neurology, Georg-August University Göttingen, Göttingen, Germany.
Z Gerontol Geriatr. 2011 Aug;44(4):268-9. doi: 10.1007/s00391-011-0213-2.
An 85-year-old man with myasthenia gravis was successfully treated with methotrexate (10 mg/week), pyridostigmine and prednisolone (0-30 mg/day) for over 10 years. Then, he developed dysphagia and lost weight. Gastroscopy revealed Candida esophagitis. The patient received nystatin for 2 weeks. Methotrexate was stopped, and immunosuppressive therapy was continued with prednisolone alone. The patient has now remained in good condition for over 1 year. Although dysphagia is a typical symptom of myasthenia gravis, swallowing disturbances should not be attributed hastily to this disease, since they may also be a complication of therapy.
一名85岁重症肌无力男性患者接受甲氨蝶呤(10毫克/周)、吡啶斯的明和泼尼松龙(0 - 30毫克/天)成功治疗超过10年。随后,他出现吞咽困难并体重减轻。胃镜检查显示念珠菌食管炎。患者接受制霉菌素治疗2周。停用甲氨蝶呤,仅继续使用泼尼松龙进行免疫抑制治疗。该患者目前状况良好已超过1年。虽然吞咽困难是重症肌无力的典型症状,但吞咽障碍不应草率地归因于该疾病,因为它们也可能是治疗的并发症。