Department of Genetics and Biochemistry, Clemson University, SC 29634-0318, USA.
Mamm Genome. 2011 Aug;22(7-8):476-85. doi: 10.1007/s00335-011-9348-0. Epub 2011 Jul 6.
The domestic dog is of great benefit to humankind, not only through companionship and working activities cultivated through domestication and selective breeding, but also as a model for biomedical research. Many single-gene traits have been well-characterized at the genomic level, and recent advances in whole-genome association studies will allow for better understanding of complex, multigenic hereditary diseases. Additionally, the dog serves as an invaluable large animal model for assessment of novel therapeutic agents. Thus, the dog has filled a crucial step in the translation of basic research to new treatment regimens for various human diseases. Four well-characterized diseases in canine models are discussed as they relate to other animal model availability, novel therapeutic approach, and extrapolation to human gene therapy trials.
家犬对人类有很大的好处，不仅通过驯化和选择性繁殖培养了陪伴和工作活动，而且还作为生物医学研究的模型。许多单基因性状已经在基因组水平上得到了很好的描述，全基因组关联研究的最新进展将有助于更好地理解复杂的多基因遗传性疾病。此外，狗作为一种非常有价值的大型动物模型，可用于评估新型治疗药物。因此，狗在将基础研究转化为治疗各种人类疾病的新疗法方面发挥了至关重要的作用。本文将讨论犬模型中四种特征明确的疾病，因为它们与其他动物模型的可用性、新的治疗方法以及对人类基因治疗试验的推断有关。
