Nucera Silvia, Biziato Daniela, De Palma Michele
San Raffaele Scientific Institute, Milan, Italy.
Int J Dev Biol. 2011;55(4-5):495-503. doi: 10.1387/ijdb.103227sn.
During organ development and remodeling, macrophages support angiogenesis, not only by secreting proangiogenic growth factors and matrix-remodeling proteases, but also by physically interacting with the sprouting vasculature to assist the formation of complex vascular networks. Recent data further indicate that embryonic and tumor-associated macrophages express similar genetic programs, possibly suggesting convergent functions in organogenesis and tumorigenesis. In this article, we review the role of macrophages in development, tissue injury and regeneration, by focusing on the mechanisms used by subsets of these cells, such as the TIE2-expressing macrophages, to regulate angiogenesis and lymphangiogenesis in both fetal and post-natal life.
在器官发育和重塑过程中，巨噬细胞不仅通过分泌促血管生成生长因子和基质重塑蛋白酶来支持血管生成，还通过与新生血管进行物理相互作用来协助形成复杂的血管网络。最新数据进一步表明，胚胎期和肿瘤相关巨噬细胞表达相似的基因程序，这可能暗示它们在器官发生和肿瘤发生过程中具有趋同功能。在本文中，我们将重点关注这些细胞亚群（如表达TIE2的巨噬细胞）在胎儿期和出生后生活中调节血管生成和淋巴管生成所采用的机制，从而综述巨噬细胞在发育、组织损伤和再生中的作用。
