Kherbèche H
Praxisassistenzarzt in allgemeinmedizinischer Hausarztpraxis, Thal.
Praxis (Bern 1994). 2011 Jul 6;100(14):865-7. doi: 10.1024/1661-8157/a000595.
A 75 year old woman presented with long-lasting pruritus and elevation of serum levels of alkaline phosphatase and gamma-glutamyl transpeptidase (GGT). Potentially hepatotoxic drugs were stopped; an abdominal ultra-sonography was normal. Antimitochondrial antibodies were elevated and are the serologic hallmark of primary biliary cirrhosis. The disease can progress from an asymptomatic inflammation to a cirrhosis. The disease-modifying treatment consists in ursodeoxycholic acid 13-15 mg/kg per day. Concomitant to the primary biliary cirrhosis hypothyroidism, osteoporosis, malabsorption and dyslipidemia can occur.
一名75岁女性出现长期瘙痒，血清碱性磷酸酶和γ-谷氨酰转肽酶（GGT）水平升高。停用了可能具有肝毒性的药物；腹部超声检查正常。抗线粒体抗体升高，这是原发性胆汁性肝硬化的血清学标志。该疾病可从无症状炎症发展为肝硬化。疾病改善治疗包括每天服用熊去氧胆酸13 - 15毫克/千克。原发性胆汁性肝硬化可能伴有甲状腺功能减退、骨质疏松、吸收不良和血脂异常。
