Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710, United States.
Environ Sci Technol. 2011 Sep 1;45(17):7510-6. doi: 10.1021/es2012275. Epub 2011 Aug 1.
Serum samples collected from California women at different time periods: 1960s (n = 40), 1980s (n = 30), and 2009 (n = 35) were examined for the presence of 12 perfluorinated compounds (PFCs) using an online SPE-HPLC-MS/MS method. At each time period, perfluorooctane sulfonate (PFOS) was present at the highest concentration, followed by perfluorooctanoic acid (PFOA, except in the 1960s). We found the highest levels of PFOS (median = 42.1 ng/mL) and perfluorohexane sulfonate (PFHxS, median = 1.56 ng/mL) in the 1960s samples, possibly reflecting widespread use of precursor PFCs. PFOS showed a statistically significant drop from the 1960s to the 1980s (28.8 ng/mL ) and to 2009 (9.0 ng/mL ), the latter being in agreement with national data. For PFOA, there was an approximately 10-fold increase in median concentrations from the 1960s (0.27 ng/mL) to the 1980s (2.71 ng/mL), and a slight drop in the 2009 samples (2.08 ng/mL). For longer chain perfluorocarboxylic acids (PFCAs), there was a continuous build-up in serum from the 1960s to 2009. To our knowledge, this is the first study to investigate temporal changes of PFCs over the past 50 years.
收集了来自加利福尼亚州不同时期（20 世纪 60 年代（n = 40）、20 世纪 80 年代（n = 30）和 2009 年（n = 35））的女性血清样本，使用在线 SPE-HPLC-MS/MS 方法检测了 12 种全氟化合物（PFCs）的存在情况。在每个时期，全氟辛烷磺酸（PFOS）的浓度最高，其次是全氟辛酸（PFOA，20 世纪 60 年代除外）。我们发现 20 世纪 60 年代样本中的 PFOS（中位数= 42.1ng/ml）和全氟己烷磺酸（PFHxS，中位数= 1.56ng/ml）水平最高，这可能反映了前体 PFCs 的广泛使用。PFOS 从 20 世纪 60 年代（28.8ng/ml）到 20 世纪 80 年代（9.0ng/ml）呈统计学显著下降，与全国数据一致。对于 PFOA，从 20 世纪 60 年代（0.27ng/ml）到 20 世纪 80 年代（2.71ng/ml），中位数浓度约增加了 10 倍，2009 年样本略有下降（2.08ng/ml）。对于长链全氟羧酸（PFCAs），从 20 世纪 60 年代到 2009 年，血清中含量不断增加。据我们所知，这是第一项研究过去 50 年来 PFCs 时间变化的研究。
