Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Liver Int. 2011 Aug;31(7):1047-53. doi: 10.1111/j.1478-3231.2011.02555.x. Epub 2011 May 31.
Role of caffeine consumption in chronic hepatitis B virus (HBV)-infected patients and the interaction with alcohol consumption is unclear.
This study aimed to investigate the relationship between caffeine and alcohol consumption and liver stiffness in chronic HBV-infected patients.
Chronic HBV-infected patients who underwent transient elastography examination in 2006-2008 were studied. Advanced fibrosis was defined as liver stiffness > 9 kPa for patients with normal alanine aminotransferase (ALT) or > 12 kPa for those with elevated ALT according to previous validation study. Caffeine and alcohol consumption was recorded using a standardized questionnaire. Excessive alcohol intake was defined as 30 g/day in men and 20 g/day in women.
The liver stiffness of 1045 patients who completed the questionnaire was 8.3 ± 6.2 kPa. Two hundred and sixteen (20.7%) patients had advanced fibrosis. Ninety-five (19.0%) patients who drank ≥ 1 cup of coffee had advanced fibrosis, compared with 121 (22.2%) patients who drank < 1 cup (P = 0.21). The amount of caffeine intake had positive correlation with the amount of alcohol intake (r(s) = 0.167, P < 0.001). Although 231 (22.1%) patients reported alcohol consumption, only 11 (1%) had excessive alcohol intake. The prevalence of advanced fibrosis among patients with mild to moderate alcohol intake (26, 18.8%) was comparable to that among non-drinkers (190, 21.0%) (P = 0.57).
Caffeine intake does not affect liver stiffness in chronic HBV-infected patients. Patients who drink coffee regularly tend to drink alcohol. Most chronic HBV-infected patients do not have excessive alcohol consumption. The prevalence of advanced fibrosis among mild to moderate alcohol drinkers was low in this population.
咖啡因摄入在慢性乙型肝炎病毒（HBV）感染患者中的作用以及与饮酒的相互作用尚不清楚。
本研究旨在探讨慢性 HBV 感染患者中咖啡因和酒精摄入与肝硬度的关系。
研究了 2006-2008 年接受瞬时弹性成像检查的慢性 HBV 感染患者。根据先前的验证研究，对于正常丙氨酸氨基转移酶（ALT）的患者，将高级纤维化定义为肝硬度>9kPa；对于 ALT 升高的患者，将高级纤维化定义为肝硬度>12kPa。使用标准化问卷记录咖啡因和酒精的摄入情况。过量饮酒定义为男性每天 30g，女性每天 20g。
完成问卷的 1045 例患者的肝硬度为 8.3±6.2kPa。216 例（20.7%）患者存在高级纤维化。与每天饮用<1 杯咖啡的 121 例（22.2%）相比，每天饮用≥1 杯咖啡的 95 例（19.0%）患者存在高级纤维化（P=0.21）。咖啡因摄入量与酒精摄入量呈正相关（r(s)=0.167，P<0.001）。尽管有 231 例（22.1%）患者报告饮酒，但仅有 11 例（1%）存在过量饮酒。轻度至中度饮酒患者（26 例，18.8%）的高级纤维化患病率与非饮酒者（190 例，21.0%）相似（P=0.57）。
咖啡因摄入不会影响慢性 HBV 感染患者的肝硬度。经常喝咖啡的患者往往会饮酒。大多数慢性 HBV 感染患者没有过量饮酒。在该人群中，轻度至中度饮酒者的高级纤维化患病率较低。
