Department of Nutrition, Federal University of Pernambuco, Rua Prof. Moraes Rego 1235, Recife, PE, Brazil.
Br J Nutr. 2012 Feb;107(3):372-7. doi: 10.1017/S0007114511002947. Epub 2011 Jul 4.
We evaluated the effects of moderate- to low-intensity physical training during gestation on reflex ontogeny in neonate rats whose mothers were undernourished. Virgin female Wistar rats were divided into four groups as follows: untrained (NT, n 7); trained (T, n 7); untrained with a low-protein diet (NT+LP, n 7); trained with a low-protein diet (T+LP, n 4). Trained rats were subjected to a protocol of moderate physical training on a treadmill over a period of 4 weeks (5 d/week and 60 min/d, at 65 % of VO₂max). After confirming the pregnancy, the intensity and duration of the exercise were reduced. Low-protein groups were provided with an 8 % casein diet, and controls were provided with a 17 % casein diet. Their respective offspring were evaluated (during the 10th-17th days of postnatal life) in terms of physical feature maturation, somatic growth and reflex ontogeny. Pups born to mothers provided with the low-protein diet during gestation and lactation showed delayed physical feature and reflex maturation and a deficit in somatic growth when compared with controls. However, most of these deficiencies were attenuated in pups of undernourished mothers undergoing training. In conclusion, physical training during gestation attenuates the effects of perinatal undernutrition on some patterns of maturation in the central nervous system during development.
我们评估了妊娠期间中低强度的身体训练对母体营养不良新生大鼠反射发育的影响。处女 Wistar 大鼠被分为以下四组：未训练组（NT，n=7）；训练组（T，n=7）；低蛋白饮食未训练组（NT+LP，n=7）；低蛋白饮食训练组（T+LP，n=4）。训练大鼠在跑步机上进行了为期 4 周的中强度身体训练方案（每周 5 天，每天 60 分钟，强度为 65%最大摄氧量）。确认怀孕后，运动的强度和时间减少。低蛋白组提供 8%的酪蛋白饮食，对照组提供 17%的酪蛋白饮食。对其各自的后代（在出生后第 10-17 天）进行身体特征成熟度、体生长和反射发育的评估。与对照组相比，在母体妊娠和哺乳期接受低蛋白饮食的幼鼠的身体特征和反射成熟延迟，且体生长不足。然而，在接受训练的营养不良母亲的幼鼠中，这些缺陷中的大多数都有所减轻。总之，妊娠期间的身体训练减轻了围产期营养不良对发育过程中中枢神经系统某些成熟模式的影响。
