Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Eur J Cancer. 2011 Nov;47(16):2422-30. doi: 10.1016/j.ejca.2011.06.029. Epub 2011 Jul 4.
We conducted a meta-analysis of prospective studies to summarise the epidemiologic evidence regarding the association of body mass index (BMI) with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) incidence and NHL mortality. Pertinent studies were identified by searching PubMed (1966-May 2011) and the reference lists of retrieved articles. For each study, we estimated a relative risk (RR) for a 5 kg/m(2) increase in BMI. A random-effects model was used to combine the RR estimates from individual studies. The summary RRs for a 5 kg/m(2) increase in BMI were 1.07 (95% confidence intervals (CI), 1.04-1.10) for NHL incidence (16 studies, n=17,291 cases) and 1.14 (95% CI, 1.04-1.26) for NHL mortality (five studies, n=3407 cases). BMI was significantly positively associated with risk of diffuse large B-cell lymphoma (RR, 1.13; 95% CI, 1.02-1.26), but not other NHL subtypes. The difference in risk estimates for subtypes was not statistically significant (P=0.10). There was evidence of a nonlinear association between BMI and HL (P for nonlinearity=0.01) (five studies, n=1557 cases). The summary RRs of HL were 0.97 (95% CI, 0.85-1.12) for overweight and 1.41 (95% CI, 1.14-1.75) for obesity. These results indicate that BMI is positively associated with risk of NHL and HL as well as with NHL mortality.
我们进行了一项荟萃分析，以总结前瞻性研究中有关体重指数（BMI）与非霍奇金淋巴瘤（NHL）和霍奇金淋巴瘤（HL）发病率以及 NHL 死亡率之间关联的流行病学证据。通过在 PubMed（1966 年-2011 年 5 月）上进行检索，并查阅已检索到的文章的参考文献，确定了相关研究。对于每项研究，我们估计了 BMI 每增加 5kg/m(2)时的相对风险（RR）。使用随机效应模型合并来自个体研究的 RR 估计值。BMI 每增加 5kg/m(2)时，NHL 发病率的汇总 RR 为 1.07（95%置信区间（CI），1.04-1.10）（16 项研究，n=17,291 例），NHL 死亡率的汇总 RR 为 1.14（95% CI，1.04-1.26）（五项研究，n=3407 例）。BMI 与弥漫性大 B 细胞淋巴瘤的风险呈显著正相关（RR，1.13；95% CI，1.02-1.26），但与其他 NHL 亚型无关。各亚型的风险估计值之间的差异无统计学意义（P=0.10）。BMI 与 HL 之间存在非线性关联（非线性检验 P=0.01）（五项研究，n=1557 例）。HL 的汇总 RR 为超重者 0.97（95% CI，0.85-1.12），肥胖者 1.41（95% CI，1.14-1.75）。这些结果表明，BMI 与 NHL 和 HL 的风险以及 NHL 死亡率呈正相关。
