Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Crit Rev Oncol Hematol. 2018 Sep;129:113-123. doi: 10.1016/j.critrevonc.2018.05.018. Epub 2018 Jun 6.
The associations between anthropometric factors and non-Hodgkin's lymphoma (NHL) risk remain inconclusive. A meta-analysis was performed to clarify these associations. PubMed and Web of Science were searched for relevant prospective observational studies. A random-effects model was used to generate the summary relative risks (RRs) with 95% confidence intervals (CIs). A total of 22 prospective cohort studies, with over 20,000 NHL cases, were included in the present meta-analysis. The summary RRs of NHL risk were 1.06 (95% CI 1.03, 1.09) for each 5 kg/m increase in body mass index (BMI), 1.11 (95% CI 1.07, 1.16) for each 5 kg/m increase in BMI in early adulthood (age 18-21 years), 1.05 (95% CI 1.01, 1.09) for each 10 kg increase in weight, 1.21 (95% CI 1.15, 1.28) for each 10 kg increase in weight in early adulthood (age 18-21 years), and 1.13 (95% CI 1.10, 1.17) for each 10 cm increase in height. No association was found for waist circumference (WC) and waist-to-hip ratio. By subtypes, all anthropometric factors (but not WC) were associated with an increased risk of diffuse large B-cell lymphoma. Chronic lymphocytic leukemia/small lymphocytic lymphoma was positively associated with BMI in early adulthood and with height, whereas follicular lymphoma was only positively associated with height. In summary, BMI and weight in early adulthood may be more relevant to NHL development than current BMI and weight. These findings emphasize the importance of maintaining a healthy weight throughout the life-course, starting from early life, for NHL prevention. Increased NHL risk with taller stature, which may reflect cumulative exposure to hormones/growth factors and nutrition status in early life, further supports the relevance of early life exposure in the etiology of NHL.
人体测量因素与非霍奇金淋巴瘤（NHL）风险之间的关联仍不确定。进行了一项荟萃分析以阐明这些关联。检索了 PubMed 和 Web of Science 以获取相关的前瞻性观察研究。使用随机效应模型生成具有 95％置信区间（CI）的汇总相对风险（RR）。本荟萃分析共纳入了 22 项前瞻性队列研究，涉及超过 20000 例 NHL 病例。对于 BMI 每增加 5kg/m，NHL 风险的汇总 RR 为 1.06（95％CI 1.03，1.09），对于 BMI 在青年期（18-21 岁）每增加 5kg/m，RR 为 1.11（95％CI 1.07，1.16），对于体重每增加 10kg，RR 为 1.05（95％CI 1.01，1.09），对于体重在青年期（18-21 岁）每增加 10kg，RR 为 1.21（95％CI 1.15，1.28），对于身高每增加 10cm，RR 为 1.13（95％CI 1.10，1.17）。腰围（WC）和腰臀比与 NHL 风险无关联。按亚型分类，所有人体测量因素（但 WC 除外）与弥漫性大 B 细胞淋巴瘤的风险增加相关。慢性淋巴细胞白血病/小淋巴细胞淋巴瘤与青年期 BMI 和身高呈正相关，而滤泡性淋巴瘤仅与身高呈正相关。总之，与当前的 BMI 和体重相比，青年期的 BMI 和体重可能与 NHL 的发生更为相关。这些发现强调了在整个生命过程中保持健康体重的重要性，从生命早期开始，以预防 NHL。身材较高与 NHL 风险增加有关，这可能反映了一生中激素/生长因子和营养状况的累积暴露，进一步支持了生命早期暴露在 NHL 病因学中的相关性。
