Department of Mathematical Sciences, Aalborg University, Fredrik Bajers Vej 7G, DK-9220 Aalborg East, Denmark.
Forensic Sci Int Genet. 2012 Mar;6(2):263-7. doi: 10.1016/j.fsigen.2011.06.004. Epub 2011 Jul 5.
We discuss the model for estimating drop-out probabilities presented by Tvedebrink et al. [7] and the concerns, that have been raised. The criticism of the model has demonstrated that the model is not perfect. However, the model is very useful for advanced forensic genetic work, where allelic drop-out is occurring. With this discussion, we hope to improve the drop-out model, so that it can be used for practical forensic genetics and stimulate further discussions. We discuss how to estimate drop-out probabilities when using a varying number of PCR cycles and other experimental conditions.
我们讨论了 Tvedebrink 等人[7]提出的估计辍学概率的模型以及由此引发的关注。对该模型的批评表明，该模型并不完美。然而，该模型对于发生等位基因丢失的高级法医遗传学工作非常有用。通过这次讨论，我们希望改进辍学模型，以便将其用于实际的法医遗传学并激发进一步的讨论。我们讨论了如何在使用不同数量的 PCR 循环和其他实验条件时估计辍学概率。
