Tvedebrink Torben, Eriksen Poul Svante, Mogensen Helle Smidt, Morling Niels
Department of Mathematical Sciences, Aalborg University, Fredrik Bajers Vej 7G, DK-9220 Aalborg East, Denmark.
Forensic Sci Int Genet. 2009 Sep;3(4):222-6. doi: 10.1016/j.fsigen.2009.02.002. Epub 2009 Mar 13.
In crime cases with available DNA evidence, the amount of DNA is often sparse due to the setting of the crime. In such cases, allelic drop-out of one or more true alleles in STR typing is possible. We present a statistical model for estimating the per locus and overall probability of allelic drop-out using the results of all STR loci in the case sample as reference. The methodology of logistic regression is appropriate for this analysis, and we demonstrate how to incorporate this in a forensic genetic framework.
在有可用DNA证据的犯罪案件中，由于犯罪场景的原因，DNA数量往往很少。在这种情况下，STR分型中一个或多个真实等位基因出现等位基因脱失是有可能的。我们提出了一个统计模型，以案件样本中所有STR位点的结果为参考，来估计每个位点的等位基因脱失概率和总体概率。逻辑回归方法适用于此分析，并且我们展示了如何将其纳入法医遗传学框架。
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