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本文引用的文献

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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys.免疫和遗传因素与疫苗预防猴子黏膜感染 SIV 的相关性。
Sci Transl Med. 2011 May 4;3(81):81ra36. doi: 10.1126/scitranslmed.3002351.
2
TRIM5 is an innate immune sensor for the retrovirus capsid lattice.TRIM5 是一种天然免疫传感器，可检测逆转录病毒衣壳晶格。
Nature. 2011 Apr 21;472(7343):361-5. doi: 10.1038/nature09976.
3
Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing.通过超深度焦磷酸测序对人类和猿猴免疫缺陷病毒的宿主内多样性进行全基因组特征分析。
J Virol. 2010 Nov;84(22):12087-92. doi: 10.1128/JVI.01378-10. Epub 2010 Sep 15.
4
TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.TRIM5 抑制灵长类免疫缺陷病毒的跨物种传播，并在新物种中选择出现抗性变异体。
PLoS Biol. 2010 Aug 24;8(8):e1000462. doi: 10.1371/journal.pbio.1000462.
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Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.HIV-1 和其他灵长类慢病毒的免疫逃逸和对限制因子的拮抗作用。
Cell Host Microbe. 2010 Jul 22;8(1):55-67. doi: 10.1016/j.chom.2010.06.004.
6
Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge.恒河猴接种猴免疫缺陷病毒 SIVmac239Delta nef 后，可延迟在多次重复低剂量异源 SIV 挑战后获得感染和控制病毒复制。
J Virol. 2010 Sep;84(18):9190-9. doi: 10.1128/JVI.00041-10. Epub 2010 Jun 30.
7
TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys.TRIM5alpha 调节恒河猴的免疫缺陷病毒控制。
PLoS Pathog. 2010 Jan 22;6(1):e1000738. doi: 10.1371/journal.ppat.1000738.
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Human cellular restriction factors that target HIV-1 replication.靶向HIV-1复制的人类细胞限制因子。
BMC Med. 2009 Sep 16;7:48. doi: 10.1186/1741-7015-7-48.
9
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.用SIVsmE660或SIVmac251对恒河猴进行低剂量直肠接种可模拟HIV-1对人类的黏膜感染。
J Exp Med. 2009 May 11;206(5):1117-34. doi: 10.1084/jem.20082831. Epub 2009 May 4.
10
Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge.疫苗诱导的细胞反应在异源攻击后控制猿猴免疫缺陷病毒复制。
J Virol. 2009 Jul;83(13):6508-21. doi: 10.1128/JVI.00272-09. Epub 2009 Apr 29.

恒河猴 TRIM5{alpha} 基因型影响重复限剂量直肠内挑战后获得猴免疫缺陷病毒 SIVsmE660 感染。

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge.

机构信息

AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, WI 53711, USA.

出版信息

J Virol. 2011 Sep;85(18):9637-40. doi: 10.1128/JVI.05074-11. Epub 2011 Jul 6.

DOI:10.1128/JVI.05074-11
PMID:21734037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165772/
Abstract

It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5(TFP) and TRIM5(CypA) alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other TRIM5 allele combinations. Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses.

摘要

最近的研究表明，恒河猴 TRIM5 基因座的多态性可能会影响猿猴免疫缺陷病毒（SIV）的复制。本研究表明，TRIM5 等位基因也会影响 SIVsmE660 的获得性感染。在重复给予限制剂量的直肠内攻击后，与表达其他 TRIM5 等位基因组合的动物相比，共表达 TRIM5(TFP)和 TRIM5(CypA)等位基因的动物感染 SIVsmE660 的时间明显延长，但对 SIVmac239 的感染时间没有明显影响。我们的研究结果表明，TRIM5 等位基因可能是产生性感染的障碍，在使用 SIVsmE660 或相关病毒进行获得性感染研究时应考虑这一点。