肯尼亚人类虫媒病毒感染的血清学证据。
Serologic evidence of arboviral infections among humans in Kenya.
机构信息
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
Am J Trop Med Hyg. 2011 Jul;85(1):158-61. doi: 10.4269/ajtmh.2011.10-0203.
Outbreaks of arthropod-borne viral infections occur periodically across Kenya. However, limited surveillance takes place during interepidemic periods. Using serum samples obtained from asymptomatic persons across Kenya in 2000-2004, we assessed (by indirect immunofluorescent assay) prevalence of IgG against yellow fever virus (YFV), West Nile virus (WNV), tick-borne encephalitis virus (TBEV), dengue virus serotypes 1-4 (DENV1-4), and chikungunya virus (CHIKV). Older persons on the Indian Ocean coast were more likely to be seropositive than children inland: YFV = 42% versus 6%, WNV = 29% versus 6%, TBEV = 16% versus 6%, DENV-1 = 63% versus 9%, DENV-2 = 67% versus 7%, DENV-3 = 55% versus 6%, DENV-4 = 44% versus 8%, and CHIKV = 37% versus 20%. Among inland samples, children in lowlands were more likely to be seropositive for CHIKV (42% versus 0%) than children in highlands. In Kenya, transmission of arboviral infection continues between known epidemics and remains common across the country.
肯尼亚周期性发生虫媒病毒感染疫情，但在疫情间歇期监测工作有限。我们利用 2000 年至 2004 年期间在肯尼亚各地无症状人群中获得的血清样本，通过间接免疫荧光检测，评估了黄热病病毒（YFV）、西尼罗河病毒（WNV）、蜱传脑炎病毒（TBEV）、登革热病毒血清型 1-4（DENV1-4）和基孔肯雅热病毒（CHIKV）的 IgG 抗体流行率。印度洋沿岸的老年人比内陆地区的儿童更有可能呈血清阳性：YFV = 42%对 6%，WNV = 29%对 6%，TBEV = 16%对 6%，DENV-1 = 63%对 9%，DENV-2 = 67%对 7%，DENV-3 = 55%对 6%，DENV-4 = 44%对 8%，CHIKV = 37%对 20%。在内陆地区的样本中，低地儿童比高地儿童更有可能呈基孔肯雅热病毒血清阳性（42%对 0%）。在肯尼亚，虫媒病毒感染的传播在已知疫情之间持续进行，而且在全国范围内仍然很常见。
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