Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
J Cardiopulm Rehabil Prev. 2011 Sep-Oct;31(5):282-9. doi: 10.1097/HCR.0b013e318220a7eb.
To describe and assess the effectiveness of a lifestyle intervention program (Met Fit) designed to treat the metabolic syndrome (MetSyn) in a cardiac rehabilitation setting.
Met Fit is a physician referred and patient pay ($350) program consisting of 12 weekly sessions of 45 minutes of exercise and 45 minutes of education with target exercise recommendations of 150 to 200 minutes weekly and 5% loss in body weight using a Mediterranean-style diet. Primary outcomes are compliance with program recommendations and secondary outcomes effecting MetSyn components.
Patients (N = 126) were enrolled between June 2005 and July 2009 averaging 9 per class. Mean (SD) age was 51(12) years, body mass index 38(6.9) kg/m, high density lipoprotein-cholesterol for men 37(9.4) mg/dL and women 46(10) mg/dL, glucose 121(39) mg/dL, and homeostatic model assessment of insulin resistance 7.2(6.1). For the 93 (73.8%) patients for whom there was complete data, mean weight loss was 6.2(6.9) lbs, [corrected] 63.4% lost at least 4 lbs, [corrected] and 19.4% lost more than 5% of weight. Significant reductions were observed in the waist circumference and body fat, and systolic and diastolic blood pressure. Triglycerides decreased significantly in both diabetics and nondiabetics but glucose decreased significantly only in diabetics. At baseline, 51% had evidence of depression, which decreased to 24.7% at 12 weeks. At program completion, 18 patients (19.4%) no longer had the MetSyn and 39 (41.9%) lost at least 1 criterion (P < .0001).
A 12-week patient-pay lifestyle interventional program conducted in a cardiac rehabilitation setting can result in a highly significant benefit to patients with the MetSyn.
描述并评估一种生活方式干预计划（Met Fit）的效果，该计划旨在心脏康复环境中治疗代谢综合征（MetSyn）。
Met Fit 是一项由医生推荐且患者付费（350 美元）的计划，包括 12 周每周 45 分钟的运动和 45 分钟的教育，目标运动推荐量为每周 150-200 分钟，体重减轻 5%，采用地中海式饮食。主要结局是遵守计划建议，次要结局影响 MetSyn 成分。
2005 年 6 月至 2009 年 7 月期间共纳入 126 名患者，平均每班 9 名。平均（SD）年龄为 51（12）岁，体重指数 38（6.9）kg/m，男性高密度脂蛋白胆固醇 37（9.4）mg/dL，女性 46（10）mg/dL，血糖 121（39）mg/dL，胰岛素抵抗稳态模型评估值 7.2（6.1）。对于 93 名（73.8%）完成完整数据的患者，平均体重减轻 6.2（6.9）磅，[纠正]63.4%至少减轻 4 磅，[纠正]19.4%减轻超过 5%的体重。腰围、体脂、收缩压和舒张压均显著降低。糖尿病患者和非糖尿病患者的甘油三酯均显著降低，但仅糖尿病患者的血糖显著降低。基线时，51%的患者有抑郁证据，12 周后降至 24.7%。在计划完成时，18 名患者（19.4%）不再患有 MetSyn，39 名患者（41.9%）至少失去了一个标准（P<.0001）。
在心脏康复环境中进行的为期 12 周的患者付费生活方式干预计划可以为患有 MetSyn 的患者带来显著的益处。
