Joseph Megan S, Konerman Monica A, Zhang Min, Wei Boxian, Brinza Ellen, Walden Patrick, Jackson Elizabeth A, Rubenfire Melvyn
Division of Cardiovascular Medicine, Michigan Medicine, Ann Arbor, MI, USA,
Division of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, MI, USA.
Diabetes Metab Syndr Obes. 2018 Nov 15;11:753-759. doi: 10.2147/DMSO.S175858. eCollection 2018.
Metabolic syndrome is associated with an increased risk of cardiovascular disease and multiple other chronic health conditions. Studies have demonstrated the effectiveness of structured diet and exercise programs to improve the components of metabolic syndrome. The durability of these benefits after program completion is unclear. The aim of this study was to evaluate trends in cardiovascular risk factors 12 months post completion of a 12- or 24-week structured lifestyle intervention program.
Individuals with metabolic syndrome were referred to the Metabolic Fitness program, a 12- or 24-week lifestyle intervention program consisting of weekly exercise and nutrition education sessions. Patients were assessed at baseline, 12 weeks, and 24 weeks for those in the 24-week program. Data collection included weight, body mass index, waist circumference, body composition percentage, sBP, dBP, fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Unstructured follow-up data were obtained by retrospective chart review for up to 12 months post program completion.
Two-hundred twenty-five patients were enrolled in the 12-week program and 121 in the 24-week program. At the conclusion of the 12-week program, patients showed significant improvement in sBP and dBP. At the conclusion of the 24-week program, patients showed significant improvement in body mass index, weight, sBP, dBP, fasting blood glucose, total cholesterol, and triglycerides. However, 12 months after program completion, while the majority of parameters were still improved compared with baseline, only change in low-density lipoprotein cholesterol remained significantly improved compared with the end of 12-week program, and sBP had increased back above baseline in both programs.
Patients with metabolic syndrome participating in a structured lifestyle intervention program show significant improvement in their cardiovascular risk and metabolic profile at program completion. The durability of these improvements appears to wane over time, however, stressing the need for programs that can facilitate maintenance of long-term behavior change.
代谢综合征与心血管疾病及多种其他慢性健康状况的风险增加相关。研究已证明结构化饮食和运动计划对改善代谢综合征的各项指标有效。这些益处计划完成后的持续性尚不清楚。本研究的目的是评估在完成12周或24周结构化生活方式干预计划12个月后心血管危险因素的变化趋势。
患有代谢综合征的个体被转介至代谢健康计划，这是一个为期12周或24周的生活方式干预计划，包括每周的运动和营养教育课程。对于参加24周计划的患者，在基线、12周和24周时进行评估。数据收集包括体重、体重指数、腰围、身体成分百分比、收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇。通过回顾性病历审查获得计划完成后长达12个月的非结构化随访数据。
225名患者参加了12周计划，121名患者参加了24周计划。在12周计划结束时，患者的收缩压和舒张压有显著改善。在24周计划结束时，患者的体重指数、体重、收缩压、舒张压、空腹血糖、总胆固醇和甘油三酯有显著改善。然而，在计划完成12个月后，虽然大多数参数仍比基线有所改善，但与12周计划结束时相比，只有低密度脂蛋白胆固醇的变化仍有显著改善，并且在两个计划中收缩压均回升至基线以上。
参加结构化生活方式干预计划的代谢综合征患者在计划完成时心血管风险和代谢指标有显著改善。然而，这些改善的持续性似乎会随着时间减弱，这强调了需要有能够促进长期行为改变维持的计划。
