癌症生物学与 NuRD：多功能染色质重塑复合物
Cancer biology and NuRD: a multifaceted chromatin remodelling complex.
机构信息
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina NC 27709, USA.
出版信息
Nat Rev Cancer. 2011 Jul 7;11(8):588-96. doi: 10.1038/nrc3091.
Abstract
The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex regulates gene expression at the level of chromatin. The NuRD complex has been identified - using both genetic and molecular analyses - as a key determinant of differentiation in mouse embryonic stem cells and during development in various model systems. Similar to other chromatin remodellers, such as SWI/SNF and Polycomb complexes, NuRD has also been implicated in the regulation of transcriptional events that are integral to oncogenesis and cancer progression. Emerging molecular details regarding the recruitment of NuRD to specific loci during development, and the modulation of these events in cancer, are used to illustrate how the inappropriate localization of the complex could contribute to tumour biology.
摘要
核小体重塑和组蛋白去乙酰化酶（NuRD；也称为 Mi-2）复合物在染色质水平上调节基因表达。NuRD 复合物已通过遗传和分子分析被鉴定为小鼠胚胎干细胞分化和各种模型系统发育过程中的关键决定因素。与其他染色质重塑复合物（如 SWI/SNF 和 Polycomb 复合物）类似，NuRD 也与肿瘤发生和癌症进展中涉及的转录事件的调节有关。在发育过程中 NuRD 复合物被招募到特定基因座的分子细节的出现，以及这些事件在癌症中的调节，被用来说明复合物的不当定位如何导致肿瘤生物学。
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