Department of Psychology and Social Behavior, School of Social Ecology, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA 92697-7085, USA.
J Autism Dev Disord. 2012 Jun;42(6):929-36. doi: 10.1007/s10803-011-1318-6.
To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB.
为了研究神经毒性物质暴露与神经心理障碍和儿童行为之间可能存在的联系，研究人员检测了自闭症谱系障碍（ASD）儿童、具有高度破坏性行为（HDB）的儿童和正常发育（TD）儿童的乳牙出生前和出生后的牙釉质中铅、汞和锰的相对浓度。研究人员使用激光烧蚀电感耦合等离子体质谱法发现，与 TD 儿童相比，ASD 儿童体内这些神经毒性物质的水平没有显著差异，但有一定的意义表明，ASD 儿童体内的锰含量较低。具有 HDB 的儿童与 TD 儿童之间没有出现显著差异。目前的研究结果对围产期重金属暴露是导致 ASD 和 HDB 发展的主要因素这一观点提出了挑战。
