Fedorowicz Zbys, Lawrence David, Gutierrez Peter, van Zuuren Esther J
UKCC (Bahrain Branch), Ministry of Health, Bahrain, Box 25438, Awali, Bahrain.
Cochrane Database Syst Rev. 2011 Jul 6(7):CD004242. doi: 10.1002/14651858.CD004242.pub4.
Age-related cataract accounts for more than 40% of cases of blindness in the world with the majority of people who are blind from cataract found in the developing world. With the increased number of people with cataract there is an urgent need for cataract surgery to be made available as a day care procedure.
To provide reliable evidence for the safety, feasibility, effectiveness and cost-effectiveness of cataract extraction performed as day care versus in-patient procedure.
We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2011, Issue 5), MEDLINE (January 1950 to May 2011), EMBASE (January 1980 to May 2011), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to May 2011), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) and ClinicalTrials.gov (www.clinicaltrials.gov). There were no date or language restrictions in the electronic searches for trials. The electronic databases were last searched on 23 May 2011.
We included randomised controlled trials comparing day care and in-patient surgery for age-related cataract. The primary outcome was the achievement of a satisfactory visual acuity six weeks after the operation.
Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information. Adverse effects information was collected from the trials.
We included two trials (conducted in Spain and USA), involving 1284 people. One trial reported statistically significant differences in early postoperative complication rates in the day care group, with an increased risk of increased intraocular pressure, which had no clinical relevance to visual outcomes four months postoperatively. The mean change in visual acuity (Snellen lines) of the operated eye four months postoperatively was 4.1 (standard deviation (SD) 2.3) for the day care group and 4.1 (SD 2.2) for the in-patient group and not statistically significant. The four-month postoperative mean change in quality of life score measured using the VF14 showed minimal differences between the two groups. Costs were 20% more for the in-patient group and this was attributed to higher costs for overnight stay. One study only reported hotel costs for the non-hospitalised participants making aggregation of data on costs impossible.
AUTHORS' CONCLUSIONS: This review provides some evidence that there is a cost saving but no significant difference in outcome or risk of postoperative complications between day care and in-patient cataract surgery. This is based on one detailed and methodologically sound trial conducted in the developed world. The success, safety and cost-effectiveness of cataract surgery as a day care procedure appear to be acceptable. Future research may well focus on evidence provided by high quality clinical databases and registers which would enable clinicians and healthcare planners to agree clinical and social indications for in-patient care and so make better use of resources, by selecting day case surgery unless these criteria are met.
年龄相关性白内障占全球失明病例的40%以上,大多数因白内障致盲的人在发展中国家。随着白内障患者数量的增加,迫切需要将白内障手术作为日间手术提供。
为日间手术与住院手术治疗年龄相关性白内障的安全性、可行性、有效性和成本效益提供可靠证据。
我们检索了Cochrane中心对照试验注册库(CENTRAL)(其中包含Cochrane眼科和视力组试验注册库)(《Cochrane图书馆》2011年第5期)、MEDLINE(1950年1月至2011年5月)、EMBASE(1980年1月至2011年5月)、拉丁美洲和加勒比卫生科学文献数据库(LILACS)(1982年1月至2011年5月)、对照试验元注册库(mRCT)(www.controlled-trials.com)和ClinicalTrials.gov(www.clinicaltrials.gov)。电子检索试验时没有日期或语言限制。电子数据库最后一次检索时间为2011年5月23日。
我们纳入了比较日间手术和住院手术治疗年龄相关性白内障的随机对照试验。主要结局是术后六周达到满意的视力。
两位作者独立评估试验质量并提取数据。我们联系研究作者获取更多信息。从试验中收集不良反应信息。
我们纳入了两项试验(分别在西班牙和美国进行),涉及1284人。一项试验报告日间手术组术后早期并发症发生率有统计学显著差异,眼内压升高风险增加,但这与术后四个月的视力结果无临床相关性。日间手术组术后四个月患眼视力(Snellen视力表行数)的平均变化为4.1(标准差(SD)2.3),住院手术组为4.1(SD 2.2),无统计学显著差异。使用VF14测量的术后四个月生活质量评分的平均变化在两组之间差异极小。住院手术组的费用高出20%,这归因于过夜住院费用较高。一项研究仅报告了非住院参与者的酒店费用,因此无法汇总成本数据。
本综述提供了一些证据表明,日间手术与住院白内障手术相比可节省成本,但在结局或术后并发症风险方面无显著差异。这是基于在发达国家进行的一项详细且方法学合理的试验。白内障手术作为日间手术的成功率、安全性和成本效益似乎是可以接受的。未来的研究很可能聚焦于高质量临床数据库和注册库提供的证据,这将使临床医生和医疗保健规划者能够确定住院治疗的临床和社会指征,从而通过选择日间手术更好地利用资源,除非满足这些标准。