肝脏再生过程中的果糖-2,6-二磷酸和6-磷酸果糖-2-激酶
Fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase during liver regeneration.
作者信息
Rosa J L, Ventura F, Carreras J, Bartrons R
机构信息
Departement de Ciències Fisiològiques Humanes i de la Nutrició, Universitat de Barcelona, L'Hospitalet, Spain.
出版信息
Biochem J. 1990 Sep 15;270(3):645-9. doi: 10.1042/bj2700645.
Abstract
Glycogen and fructose 2,6-bisphosphate levels in rat liver decreased quickly after partial hepatectomy. After 7 days the glycogen level was normalized and fructose 2,6-bisphosphate concentration still remained low. The 'active' (non-phosphorylated) form of 6-phosphofructo-2-kinase varied in parallel with fructose 2,6-bisphosphate levels, whereas the 'total' activity of the enzyme decreased only after 24 h, similarly to glucokinase. The response of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from hepatectomized rats (96 h) to sn-glycerol 3-phosphate and to cyclic AMP-dependent protein kinase was different from that of the enzyme from control animals and similar to that of the foetal isoenzyme.
摘要
大鼠肝脏部分切除术后，肝糖原和果糖2,6-二磷酸水平迅速下降。7天后，肝糖原水平恢复正常，而果糖2,6-二磷酸浓度仍维持在低水平。6-磷酸果糖-2-激酶的“活性”（非磷酸化）形式与果糖2,6-二磷酸水平平行变化，而该酶的“总”活性仅在24小时后下降，与葡萄糖激酶情况相似。肝切除大鼠（96小时）的6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶对3-磷酸甘油和环磷酸腺苷依赖性蛋白激酶的反应与对照动物的该酶不同，与胎儿同工酶的反应相似。
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