Nowak Katarzyna, Szyfter Witold
Klinika Otolaryngologii i Onkologii, Laryngologicznej Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Poznań.
Otolaryngol Pol. 2011 Mar-Apr;65(2):103-5. doi: 10.1016/S0030-6657(11)70637-0.
Persistent, intrinsic rhinitis is common disease of heterogeneous etiology, often not responsive or poorly responsive to standard medical therapy. To assess the action of botulinum toxin type A--strong and long-acting cholinergic blocker--administered intranasally in the form of injection to the nasal turbinates or influenced Merocel to diminish the symptoms of patients reporting symptoms such as stuffy nose, sneezing, runny nose.
The study included 17 patients with chronic intrinsic rhinitis. Five patients received injections of Botox in a dose of 10 U the lower and the middle nasal concha, ten patients are in the same way 20 U of Botox, two patients were applied to 40 U of Botox in the influenced Merocel.
All patients had an improvement, which concerned all the previously reported symptoms associated with rhinitis, the full effect of the toxin appeared in these patients within 1-2 weeks after application and lasted, depending on the dose of 8-12 weeks. After this time, the effect of explicitly and has declined sharply, which is sometimes associated with the activity of natural toxins.
Botulinum toxin type A used intranasally in intrinsic rhinitis is a new, effective method that allows good control of symptoms of the patient. The only limitation of its use is the high price of botulinum.
持续性特发性鼻炎是一种病因多样的常见疾病，通常对标准药物治疗无反应或反应不佳。为评估A型肉毒杆菌毒素（一种强效长效胆碱能阻滞剂）以注射到鼻甲或作用于Merocel的形式经鼻给药对报告有鼻塞、打喷嚏、流鼻涕等症状的患者症状的减轻作用。
该研究纳入了17例慢性特发性鼻炎患者。5例患者在下鼻甲和中鼻甲注射10单位的保妥适，10例患者同样注射20单位的保妥适，2例患者将40单位的保妥适作用于Merocel。
所有患者均有改善，涉及所有先前报告的与鼻炎相关的症状，毒素的全部效果在应用后1至2周内在这些患者中出现，并持续8至12周，具体取决于剂量。在此之后，效果明显下降，这有时与天然毒素的活性有关。
经鼻使用A型肉毒杆菌毒素治疗特发性鼻炎是一种新的有效方法，可有效控制患者症状。其使用的唯一限制是肉毒杆菌毒素价格高昂。
