Siennicka Joanna, Stefanoff Paweł, Rogalska Justyna, Trzcińska Agnieszka
Department of Virology, National Institute of Public Health-National Institute of Hygiene, Warsaw.
Przegl Epidemiol. 2011;65(1):39-44.
To achieve measles elimination, an efficient surveillance system for rash illnesses is necessary. The aim of the present study was to ascertain which viruses, other than measles, are causing measles-like illnesses (MLIs) in Poland. Serum samples (n=278) collected from MLI cases and submitted to the National Reference Laboratory during 2006-2007 were investigated for anti-measles (MeV), rubella (RUBV), parvovirus B19 (B19V), Epstein-Barr (EBV) and herpesvirus type-6 (HHV-6) IgM presence. Age was strongly associated with MLIs etiology. In the youngest age group, 0-4 years, MeV and HHV-6 infection were prevailing, while in group of 5-9 years--RUBV and B 19V. Measles was confirmed more often in patients with high fever (p < 0.001) and with rash lasting longer than 5 days (p < 0.001). The type of rash was not significantly associated with MeV infection. Our results strongly suggest that according to WHO EURO strategic plan, Poland is close to elimination phase. High number of MLIs were caused by pathogens other than measles. Addition of anti-B 19V IgM testing to routine MLIs screening protocol may improve system performance in the more advanced stages of measles elimination.
为实现消除麻疹目标，建立一个高效的皮疹疾病监测系统很有必要。本研究旨在确定除麻疹病毒外，还有哪些病毒在波兰引发类似麻疹的疾病（MLIs）。对2006 - 2007年期间收集自MLIs病例并提交至国家参考实验室的血清样本（n = 278）进行检测，以确定是否存在抗麻疹病毒（MeV）、风疹病毒（RUBV）、细小病毒B19（B19V）、爱泼斯坦 - 巴尔病毒（EBV）和6型疱疹病毒（HHV - 6）的IgM。年龄与MLIs的病因密切相关。在最年幼的年龄组（0 - 4岁），麻疹病毒和HHV - 6感染最为常见，而在5 - 9岁年龄组，则以风疹病毒和B19V为主。麻疹在高热患者中更常被确诊（p < 0.001），且皮疹持续超过5天的患者中也更常被确诊（p < 0.001）。皮疹类型与麻疹病毒感染无显著相关性。我们的结果强烈表明，根据世界卫生组织欧洲区域战略计划，波兰已接近消除阶段。大量的MLIs是由麻疹以外的病原体引起的。在常规MLIs筛查方案中增加抗B19V IgM检测可能会提高麻疹消除更高级阶段的系统性能。
