Qian Z W, Mao S J, Cai X C, Zhang X L, Gao F X, Lu M F, Shao X S, Li Y Y, Yang X K, Zhuo Y A
Beijing Tian Tan Hospital.
Chin Med J (Engl). 1990 Aug;103(8):647-51.
Chronic cervicitis was shown to be related to papillomavirus type 16(HPV-16), herpes simplex virus type 2 and cytomegalovirus (CMV) infections as demonstrated by DNA hybridization technique and virus isolation method from samples taken from erosive and normal cervices. After one course of treatment with recombinant interferon alpha 1 (rIFN-alpha 1), 93.8% of cases showed clinical improvement and 60% marked improvement. The HPV-16 and HSV detection rates dropped down significantly after rIFN-alpha 1 treatment as compared with those before treatment. Astragalus membranaceus, a Chinese herbal drug, was shown to be synergic to interferon therapy.
通过对糜烂性和正常宫颈样本进行DNA杂交技术和病毒分离方法检测发现，慢性宫颈炎与16型乳头瘤病毒（HPV - 16）、2型单纯疱疹病毒及巨细胞病毒（CMV）感染有关。用重组α1干扰素（rIFN - α1）治疗一个疗程后，93.8%的病例显示临床症状改善，60%显著改善。与治疗前相比，rIFN - α1治疗后HPV - 16和HSV的检出率显著下降。黄芪，一种中草药，被证明与干扰素治疗具有协同作用。
